Recent Findings in Antioxidants and Redox Signaling Described by Researchers from Federal University (Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Life Science Research. According to news reporting originating in Sao Paulo, Brazil, by NewsRx journalists, research stated, "Aging is a multi-factorial process that may be associated with several functional and structural deficits which can evolve into degenerative diseases. In this review, we present data that may depict an expanded view of molecular aging theories, beginning with the idea that reactive oxygen species (ROS) are the major effectors in this process."
According to the news reporters, the research concluded: "Aging is a multi-factorial process that may be associated with several functional and structural deficits which can evolve into degenerative diseases. In this review, we present data that may depict an expanded view of molecular aging theories, beginning with the idea that reactive oxygen species (ROS) are the major effectors in this process. In addition, we have correlated the importance of autophagy as a neuroprotective mechanism and discussed a link between age-related molecules, Ca2+ signaling, and oxidative stress. Recent Advances: There is evidence suggesting that alterations in Ca2+ homeostasis, including mitochondrial Ca2+ overload and alterations in electron transport chain (ETC) complexes, which increase cell vulnerability, are linked to oxidative stress in aging. As much as Ca2+ signaling is altered in aged cells, excess ROS can be produced due to an ineffective coupling of mitochondrial respiration. Damaged mitochondria might not be removed by the macroautophagic system, which is hampered in aging by lipofuscin accumulation, boosting ROS generation, damaging DNA, and, ultimately, leading to apoptosis. Critical Issues: This process can lead to altered protein expression (such as p53, Sirt1, and IGF-1) and progress to cell death. This cycle can lead to increased cell vulnerability in aging and contribute to an increased susceptibility to degenerative processes. Future Directions: A better understanding of Ca2+ signaling and molecular aging alterations is important for preventing apoptosis in age-related diseases. In addition, caloric restriction, resveratrol and autophagy modulation appear to be predominantly cytoprotective, and further studies of this process are promising in age-related disease therapeutics."
For more information on this research see: Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging. Antioxidants & Redox Signaling, 2014;21(1):123-137. Antioxidants & Redox Signaling can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Antioxidants & Redox Signaling - www.liebertpub.com/overview/antioxidants-and-redox-signaling/4/)
Our news correspondents report that additional information may be obtained by contacting R.P. Ureshino, Federal University of Sao Paulo, Dept. of Pharmacol, BR-04044020 Sao Paulo, Brazil. Additional authors for this research include K.K. Rocha, G.S. Lopes, C. Bincoletto and S.S. Smaili (see also Life Science Research).
Keywords for this news article include: Brazil, Sao Paulo, South America, Life Science Research
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