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Skeletal muscle mitochondrial function studied, age-related decline described



Recently published research from the United States has described a decline in skeletal muscle mitochondrial function with aging in humans.

"Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to accelerate aging in mice. We determined whether aging results in increased DNA oxidative damage and reduced mtDNA abundance and mitochondrial function in skeletal muscle of human subjects," wrote K.R. Short and colleagues, Mayo Clinic & Mayo Foundation.

"Studies performed in 146 healthy men and women aged 18-89 yr demonstrated that mtDNA and mRNA abundance and mitochondrial ATP production all declined with advancing age. Abundance of mtDNA was positively related to mitochondrial ATP production rate, which in turn, was closely associated with aerobic capacity and glucose tolerance.

"The content of several mitochondrial proteins was reduced in older muscles, whereas the level of the oxidative DNA lesion, 8-oxo-deoxy-guanosine, was increased, supporting the oxidative damage theory of aging," reported the authors.

"These results demonstrate that age-related muscle mitochondrial dysfunction is related to reduced mtDNA and muscle functional changes that are common in the elderly," the investigators concluded.

Short and colleagues published their study in Proceedings of the National Academy of Sciences of the United States of America (Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA, 2005;102(15):5618-5623).

For additional information, contact K.S. Nair, Mayo Clinic & Mayo Foundation, Endocrine Research Unit, 200 1st St. SW, Rochester, MN 55905, USA.

Publisher contact information for the journal Proceedings of the National Academy of Sciences of the United States of America is: National Academy of Sciences, 2101 Constitution Avenue NW, Washington, DC 20418, USA.

Keywords: Rochester, Minnesota, United States, Aging, Sarcopenia, Mitochondrial DNA, Mitochondrial Proteins, mtDNA, Oxidative Damage, Skeletal Muscle. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2005, Proteomics Weekly via NewsRx.com.

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© 2004 NewsRx.com. All Rights Reserved.&#169Copyright 2005, Proteomics Weekly via NewsRx.com

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