By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on Nervous System Diseases and Conditions are discussed in a new report. According to news reporting from Atlanta, Georgia, by NewsRx journalists, research stated, "Progesterone (PROG) has been shown to protect the brain from traumatic injury and is now in Phase III clinical trials. Our work shows that PROG's beneficial effects can be reduced in vitamin D hormone (VDH)-deficient subjects."
The news correspondents obtained a quote from the research from Emory University, "VDH can modulate neuronal apoptosis, trophic factors, inflammation, oxidative stress, excitotoxicity, and myelin and axon repair. We investigated whether VDH combined with PROG could improve behavioral outcomes more than PROG alone in VDH-sufficient rats given bilateral contusions of the medial frontal cortex. PROG and different doses of VDH (1 g/kg, VDH1; 2.5 g/kg, VDH2; 5 g/kg, VDH3) were injected intraperitoneally 1 h post-injury. Eight additional doses of PROG were given subcutaneously over 8 days with tapering over the last 2 days. Neurobehavioral tests, necrotic cavity, neuronal death and activation of astrocytes were evaluated 21 days post-injury. We found that PROG and PROG + VDH preserve spatial memory processing. VDH1 + PROG improved performance in acquisition more effectively than PROG alone, indicating that the low VDH dose is optimal for combination therapy. There were no significant differences in necrotic cavity size among the groups. The density of positive staining for reactive astrocytes (glial fibrillary acidic protein (GFAP)) increased and the cell bodies and processes of GFAP-positive cells were enlarged in the PROG + VDH1 group. Our data indicate that the combination of PROG and VDH is more effective than PROG alone in preserving spatial and reference memory, and that PROG plus low-dose VDH can activateGFAP reactions up to 21 days after injury."
According to the news reporters, the research concluded: "This effect may be one of the mechanisms underlying PROG's neuroprotective effects in combination with VDH."
For more information on this research see: Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury. Hormones and Behavior, 2012;61(4):642-51. (Elsevier - www.elsevier.com; Hormones and Behavior - www.elsevier.com/wps/product/cws_home/622842)
Our news journalists report that additional information may be obtained by contacting F. Hua, Dept. of Emergency Medicine, Emory University, Atlanta, GA 30322, United States (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Atlanta, Georgia, United States, Brain Injuries, Gonadal Hormones, Craniocerebral Trauma, Corpus Luteum Hormones, Progesterone Congeners, North and Central America, Nervous System Diseases and Conditions.
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