By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Diet and Nutrition. According to news originating from Guangdong, People's Republic of China, by NewsRx correspondents, research stated, "The n-3 polyunsaturated fatty acids have been shown to inhibit the induction and progression of many kinds of tumor and to increase the therapeutic effects of numerous chemotherapeutics, but their anticancer effect on cancer stem cells from colorectal cancer has not been described previously. In the present study, we cultivated spheres from the SW620 cell line in serum-free medium and evaluated the features of the spheres by immunofluorescence, cell cycle distribution, resistance to chemotherapeutics and soft agar clone formation, and the spheres were shown to be cancer stem-like cells through tumorigenicity in athymic nude mice."
Our news journalists obtained a quote from the research from Sun Yat-Sen University, "Reverse transcriptase polymerase chain reaction analysis of pluripotency genes, such as Sox-2, Oct-4 and Bmi-1, showed that the spheres were generated by dedifferentiation of SW620 cells. The study explored the use of n-3 polyunsaturated fatty acids (PUFAs) in spheres, which were treated with two n-3 PUFAs [docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA)]. Treatment of the spheres with DHA and EPA alone or in combination for 72 h led to apoptosis and the progressive loss of viability and DNA fragmentation and an increase in annexin V expression. DHA and EPA can enhance the chemotherapeutic sensitivity effect of 5-Fu and mitomycin C, especially DHA combined with EPA."
According to the news editors, the research concluded: "Taken together, these results provide evidence that n-3 PUFAs exert a direct anticancer action that may contribute to their antiproliferative and proapoptotic effect on the cancer stem-like cells."
For more information on this research see: N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. The Journal of Nutritional Biochemistry, 2013;24(5):744-53 (see also Diet and Nutrition).
The news correspondents report that additional information may be obtained from T. Yang, Dept. of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Taiwan.
Keywords for this news article include: Asia, Genetics, Oncology, Guangdong, Colorectal, Colon Cancer, Gastroenterology, Diet and Nutrition, Cancer Gene Therapy, People's Republic of China.
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