By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Fresh data on Diet and Nutrition are presented in a new report. According to news reporting originating in Suwon, South Korea, by NewsRx journalists, research stated, "Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, possesses remarkable chemopreventive and therapeutic potential against various types of cancer, including head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanism involved is not completely understood."
The news reporters obtained a quote from the research from the Ajou University School of Medicine, "Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), a transforming growth factor ?? superfamily protein, is shown to be induced by several antitumorigenic compounds and to exhibit proapoptotic and antitumorigenic activities. In this report, we demonstrate that EGCG transcriptionally induced the expression of NAG-1 during EGCG-induced apoptosis of HNSCC cells. Reporter assays, using the luciferase constructs containing the NAG-1 promoter, demonstrate that p53 is required for EGCG-mediated activation of NAG-1. Overexpression of NAG-1 enhanced the apoptotic effect of EGCG, whereas suppression of NAG-1 expression by small interfering RNA attenuated EGCG-induced apoptosis in HNSCC cells. Subsequently, we found that ataxia-telangiectasia mutated (ATM) plays an important role in activating these proapoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21). Furthermore, EGCG significantly inhibited tumor formation as assessed by xenograft models, and this result is accompanied with induction of apoptotic cells and NAG-1 expression in tumor tissue samples."
According to the news reporters, the research concluded: "Taken together, these results demonstrate for the first time that EGCG induces apoptosis via ATM/p53-dependent NAG-1 expression in HNSCC, providing an additional mechanistic explanation for the apoptotic activity of EGCG."
For more information on this research see: Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression. The Journal of Nutritional Biochemistry, 2013;24(6):986-99 (see also Diet and Nutrition).
Our news correspondents report that additional information may be obtained by contacting S.U. Kang, Dept. of Otolaryngology, Ajou University School of Medicine, 5 Wonchon-Dong, Yeongtong-Gu, Suwon 442-749, South Korea.
Keywords for this news article include: Asia, Suwon, Genetics, Oncology, p53 Gene, Apoptosis, South Korea, Diet and Nutrition, Cancer Gene Therapy.
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