By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Diet and Nutrition have been published. According to news reporting originating in Rio de Janeiro, Brazil, by NewsRx journalists, research stated, "We hypothesized that resveratrol, a natural phytoalexin found in grapes, can prevent oxidative stress, obesity and its related disturbances in obese rats programmed by early weaning. Lactating Wistar rats were separated into two groups: early weaning (EW) -dams who were wrapped with a bandage to interrupt the lactation in the last 3 days of lactation; control -dams whose pups had free access to milk during all lactation."
The news reporters obtained a quote from the research from State University, "At the 150th day, EW offspring were randomly subdivided into EW+resveratrol (EW+Res) -resveratrol (30 mg/kg/day); EW+vehicle (EW) -rats that received 0.5% (w/v) aqueous methylcellulose. The control group received vehicle. Rats were treated by gavage daily for 30 days. EW offspring developed hyperphagia, higher body weight, visceral obesity, higher systolic (SBP) and diastolic blood pressure (DBP) (+15% and +20%, respectively; p<.05) and higher serum triglycerides (TG) and low-density lipoprotein but lower high-density lipoprotein (+55%, +33% and -13%, respectively; p<.05). Resveratrol normalized food intake, SBP and DBP and prevented obesity and dyslipidemia in EW+Res. EW rats had higher plasma and liver thiobarbituric-acid-reactive substances (TBARS) and lower plasma superoxide dismutase (SOD) and liver glutathione peroxidase activities (+51%, +18%, -58%, -31%, respectively; p<.05), and resveratrol normalized both plasma and liver TBARS and increased the activity of SOD and catalase in plasma. EW rats presented liver steatosis and higher liver TG, and resveratrol prevented these hepatic alterations."
According to the news reporters, the research concluded: "This study demonstrated a potential therapeutic use of resveratrol in preventing obesity and oxidative stress and reducing the risk of hypertension, dyslipidemia and steatosis in adult rats programmed by early weaning."
For more information on this research see: Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning. The Journal of Nutritional Biochemistry, 2013;24(6):960-6 (see also Diet and Nutrition).
Our news correspondents report that additional information may be obtained by contacting J.G. Franco, Dept. of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20550-030, Brazil.
Keywords for this news article include: Blood, Brazil, Plasma, Obesity, Steatosis, Bariatrics, Hypertension, South America, Overnutrition, Rio de Janeiro, Diet and Nutrition, Nutrition Disorders, Cardiovascular Diseases.
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