By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Current study results on Heart Attack have been published. According to news reporting from Boston, Massachusetts, by NewsRx journalists, research stated, "Accumulating evidence suggests that vitamin D deficiency plays a crucial role in heart failure. However, whether vitamin D signaling itself plays an important role in cardioprotection is poorly understood."
The news correspondents obtained a quote from the research from the Beth Israel Deaconess Medical Center and Harvard University School of Medicine, "In this study, we examined the mechanism of modulating vitamin D signaling on progression to heart failure after myocardial infarction (MI) in mice. Vitamin D signaling was activated by administration of paricalcitol (PC), an activated vitamin D analog. Wild-type (WT) mice underwent sham or MI surgery and then were treated with either vehicle or PC. Compared with vehicle group, PC attenuated development of heart failure after MI associated with decreases in biomarkers, apoptosis, inflammation, and fibrosis. There was also improvement of cardiac function with PC treatment after MI. Furthermore, vitamin D receptor (VDR) mRNA and protein levels were restored by PC treatment. Next, to explore whether defective vitamin D signaling exhibited deleterious responses after MI, WT and VDR knockout (KO) mice underwent sham or MI surgery and were analyzed 4 wk after MI. VDR KO mice displayed a significant decline in survival rate and cardiac function compared with WT mice after MI. VDR KO mice also demonstrated a significant increase in heart failure biomarkers, apoptosis, inflammation, and fibrosis."
According to the news reporters, the research concluded: "Vitamin D signaling promotes cardioprotection after MI through anti-inflammatory, antifibrotic and antiapoptotic mechanisms."
For more information on this research see: Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction. Journal of Applied Physiology, 2013;114(8):979-87 (see also Heart Attack).
Our news journalists report that additional information may be obtained by contacting S. Bae, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Keywords for this news article include: Boston, Surgery, Treatment, Heart Attack, Massachusetts, United States, Heart Disease, Vascular Diseases, Myocardial Ischemia, Myocardial Infarction, North and Central America.
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