Daily News: Aging

New Findings on Alzheimer Disease Described by Investigators at Center for Bioinformation

NewsRx.com

07-12-13

By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- Current study results on Neurodegenerative Diseases have been published. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "With the growth of aging population all over the world, a rising incidence of Alzheimer's disease (AD) has been recently observed. In contrast to FDA-approved western drugs, herbal medicines, featured as abundant ingredients and multi-targeting, have been acknowledged with notable anti-AD effects although the mechanism of action (MOA) is unknown."

The news correspondents obtained a quote from the research from Center for Bioinformation, "Investigating the possible MOA for these herbs can not only refresh but also extend the current knowledge of AD pathogenesis. In this study, clinically tested anti-AD herbs, their ingredients as well as their corresponding target proteins were systematically reviewed together with applicable bioinformatics resources and methodologies. Based on above information and resources, we present a systematically target network analysis framework to explore the mechanism of anti-AD herb ingredients. Our results indicated that, in addition to the binding of those symptom-relieving targets as the FDA-approved drugs usually do, ingredients of anti-AD herbs also interact closely with a variety of successful therapeutic targets related to other diseases, such as inflammation, cancer and diabetes, suggesting the possible cross-talks between these complicated diseases. Furthermore, pathways of Ca2+ equilibrium maintaining upstream of cell proliferation and inflammation were densely targeted by the anti-AD herbal ingredients with rigorous statistic evaluation."

According to the news reporters, the research concluded: "In addition to the holistic understanding of the pathogenesis of AD, the integrated network analysis on the MOA of herbal ingredients may also suggest new clues for the future disease modifying strategies."

For more information on this research see: Towards a bioinformatics analysis of anti-Alzheimer's herbal medicines from a target network perspective. Briefings in Bioinformatics, 2013;14(3):327-343. Briefings in Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Briefings in Bioinformatics - bib.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting Y. Sun, Shanghai Center Bioinformat & Technol, Shanghai, People's Republic of China (see also Neurodegenerative Diseases).

Keywords for this news article include: Asia, Shanghai, Dementia, Tauopathies, Brain Diseases, Alzheimer Disease, People's Republic of China, Neurodegenerative Diseases, Central Nervous System Diseases

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