Daily News: Aging

Reports Summarize Dimethyl Sulfoxide Therapy Findings from Charles University

NewsRx.com

07-12-13

By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Plzen, Czech Republic, by NewsRx journalists, research stated, "DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability."

The news correspondents obtained a quote from the research from Charles University, "The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO reducing stress-induced behavioral disinhibition which is supposed to interfere with learning process in Lurcher mutants."

According to the news reporters, the research concluded: "Future studies which would investigate DMSO effects in other models of neurodegenerative diseases are necessary to verify its potential therapeutic impact."

For more information on this research see: Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice. Neuroscience Letters, 2013;543():142-145. Neuroscience Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Neuroscience Letters - www.elsevier.com/wps/product/cws_home/506081)

Our news journalists report that additional information may be obtained by contacting V. Markvartova, Charles Univ Prague, Fac Med Plzen, Biomed Center, Plzen 30166, Czech Republic (see also Drugs and Therapies).

Keywords for this news article include: Pharmaceuticals, Plzen, Europe, Czech Republic, Sulfur Compounds, Dimethyl Sulfoxide, Drugs and Therapies, Genitourinary Tract Agents

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