By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Prostate Cancer. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer."
The news reporters obtained a quote from the research from Peking University, "The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity."
According to the news reporters, the research concluded: "Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer."
For more information on this research see: Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells. Phytotherapy Research, 2013;27(6):885-891. Phytotherapy Research can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Phytotherapy Research - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1573)
Our news correspondents report that additional information may be obtained by contacting J. Tong, Peking University, Hlth Sci Center, Sch Pharmaceut Sci, Beijing 100191, People's Republic of China (see also Prostate Cancer).
Keywords for this news article include: Asia, Beijing, Caspases, Hormones, Oncology, Prostate Cancer, Peptide Hydrolases, Cancer Gene Therapy, Prostatic Neoplasms, Enzymes and Coenzymes, Cysteine Endopeptidases, People's Republic of China, Androgens and Anabolic Steroids
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