Daily News: Disease

Reports on Prostate Cancer from Tianjin Medical University Provide New Insights

NewsRx.com

08-16-13

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Prostate Cancer. According to news originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "Recent studies on the association between Glutathione S-transferase T1 (GSTT1) polymorphism and risk of prostate cancer showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies."

Our news journalists obtained a quote from the research from Tianjin Medical University, "DATA WERE COLLECTED FROM THE FOLLOWING ELECTRONIC DATABASES: Pubmed, Embase, and Chinese Biomedical Database (CBM). The odds ratio (OR) and its 95% confidence interval (95%CI) was used to assess the strength of the association. We summarized the data on the association between GSTT1 null genotype and risk of prostate cancer in the overall population, and performed subgroup analyses by ethnicity, adjusted ORs, and types of controls. Ultimately, a total of 43 studies with a total of 26,393 subjects (9,934 cases and 16,459 controls) were eligible for meta-analysis. Overall, there was a significant association between GSTT1 null genotype and increased risk of prostate cancer (OR=1.14, 95%CI 1.01-1.29, p=0.034). Meta-analysis of adjusted ORs also showed a significant association between GSTT1 null genotype and increased risk of prostate cancer (OR=1.34, 95%CI 1.09-1.64, p=0.006). Similar results were found in the subgroup analyses by ethnicity and types of controls."

According to the news editors, the research concluded: "This meta-analysis demonstrates that GSTT1 null genotype is associated with prostate cancer susceptibility, and GSTT1 null genotype contributes to increased risk of prostate cancer."

For more information on this research see: Significant association of Glutathione S-transferase T1 null genotype with prostate cancer risk: a meta-analysis of 26,393 subjects. Plos One, 2013;8(1):e53700. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

The news correspondents report that additional information may be obtained from Q. Yang, Dept. of Genitourinary Oncology, Tianjin Medical University Cancer Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Taiwan (see also Prostate Cancer).

Keywords for this news article include: Asia, Tianjin, Genetics, Oncology, Glutathione, Transferases, Oligopeptides, Prostatic Neoplasms, Risk and Prevention, Enzymes and Coenzymes, People's Republic of China, Metastatic Prostate Cancer.

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