By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Bone Disease are presented in a new report. According to news reporting out of Calgary, Canada, by NewsRx editors, research stated, "Renal transplant patients have been shown to have a higher risk of bone disease than the general population. The aim of this study was to examine vitamin D status, a modifiable risk factor in bone disease, in the renal transplant population in a northern climate."
Our news journalists obtained a quote from the research, "This retrospective observational study included 331 subjects and analyzed demographic, biochemical, and medication information for associations with vitamin D. Of the study population, 45.3% were vitamin D deficient. The percentage of deficient subjects increases to 76.5% if those receiving supplementation are excluded. The mean daily dose of vitamin D was 1275 IU for sufficient patients. For every 1000 IU of vitamin D daily, the risk of deficiency is decreased by 40.3%. Time from transplantation had a significant positive association (p <0.001) in which every year out of transplantation decreased the risk of deficiency by 9.1%. Body mass index had a significant negative association (p=0.012) with vitamin D in which the risk of deficiency increased by 6% for each kilogram per meter squared. Ethnicity was found to be statistically significant on univariate analysis (p=0.034), with white patients having 9.1% decreased risk of deficiency. Despite a high rate of supplementation of vitamin D, close to half of the renal transplant population was still deficient. Those who were receiving over 1000 IU daily were more likely to be vitamin D sufficient."
According to the news editors, the research concluded: "Early supplementation after transplantation along with higher doses for non-white patients or patients with a high body mass index may be warranted for normalization of vitamin D status."
For more information on this research see: Predicting deficiency of vitamin D in renal transplant recipients in northern climates. Transplantation, 2013;95(12):1479-84. (Lippincott Williams and Wilkins - www.lww.com; Transplantation - journals.lww.com/transplantjournal/pages/default.aspx)
Our news journalists report that additional information may be obtained by contacting L.C. Beique, Alberta Health Services-Calgary Zone, Pharmacy Services, Southern Alberta Transplant Program, Calgary, Alberta, Canada. Additional authors for this research include G.A. Kline, B. Dalton, K. Duggan and S. Yilmaz (see also Bone Disease).
Keywords for this news article include: Canada, Calgary, Alberta, Surgery, Nephrology, Bone Diseases, Renal Allograft, Organ Transplant, Renal Transplant, Kidney Transplant, Risk and Prevention, North and Central America, Clinical Trials and Studies.
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