By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on Cholesterol. According to news reporting originating in Tokushima, Japan, by NewsRx journalists, research stated, "The use of vitamin E-bonded cellulose membrane dialyzers has been reported to cause a decrease in oxidative lipid marker levels (Nakai et al., Ther Apher Dial 14:505-540, 1; Nakai et al., J Jpn Soc Dial Ther 45:1-47, 2; Mashiba et al., Arterioscler Thromb Vasc Biol 21:1801-1808, 3). However, few studies have identified this effect with vitamin E-bonded polysulfone membranes, and no studies report the same effect on alpha (1) antitrypsin-LDL complex, a new oxidative lipid marker."
The news reporters obtained a quote from the research, "This prompted us to examine the influence of use of VPS-HA vitamin E-bonded polysulfone high-flux membrane dialyzers on this new oxidative lipid marker. The subjects were 17 patients who had been dialyzed with VPS-HA for 12 months. The subjects' baseline characteristics were as follows. Their average age was 65.6 ?? 13.1 years, comprising 8 males and 9 females; hemodialysis vintage was 83.8 ?? 85.4 months. Eight had chronic glomerular nephropathy and five had diabetic nephropathy. The primary outcome was defined as alpha (1) antitrypsin-LDL complex level after 12 months, as a post-study using VPS-HA. Secondary outcomes included triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol levels. The data were analyzed pre-study and after 3, 6, 9 and 12 months for alpha (1) antitrypsin-LDL complex, and pre-study and post-study for the other indicators. Twelve months after switching to VPS-HA, alpha (1) antitrypsin-LDL complex, total cholesterol and LDL cholesterol had significantly decreased. Triglycerides and HDL cholesterol had not significantly changed."
According to the news reporters, the research concluded: "Hemodialysis therapy with VPS-HA was shown to decrease alpha (1) antitrypsin-LDL complex, an index of oxidative stress, and also to decrease some lipid markers."
For more information on this research see: The effect of vitamin E-bonded polysulfone membrane dialyzer on a new oxidative lipid marker. Journal of Artificial Organs, 2013;16(2):206-10. Journal of Artificial Organs can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Artificial Organs - www.springerlink.com/content/1434-7229/)
Our news correspondents report that additional information may be obtained by contacting Y. Kitamura, Dept. of Kidney Disease, Kawashima Hospital, Tokushima, Japan. Additional authors for this research include K. Kamimura, N. Yoshioka, Y. Hosotani, K. Tsuchida, M. Koremoto and J. Minakuchi (see also Cholesterol).
The publisher of the Journal of Artificial Organs can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, Japan, Serpins, Tokushima, Cholesterol, Glycoproteins, Alphaglobulins, Blood Proteins, alpha 1 Antitrypsin, Acute Phase Proteins.
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