Daily News: Aging

New Neuroscience Study Findings Have Been Reported by Researchers at University of Texas Health Science Center

NewsRx.com

10-04-13

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Neuroscience. According to news reporting originating from San Antonio, Texas, by NewsRx correspondents, research stated, "Aging is, by far, the greatest risk factor for most neurodegenerative diseases. In non-diseased conditions, normal aging can also be associated with declines in cognitive function that significantly affect quality of life in the elderly."

Our news editors obtained a quote from the research from the University of Texas Health Science Center, "It was recently shown that inhibition of Mammalian TOR (mTOR) activity in mice by chronic rapamycin treatment extends lifespan, possibly by delaying aging {Harrison, 2009 #4}{Miller, 2011 #168}. To explore the effect of chronic rapamycin treatment on normal brain aging we determined cognitive and non-cognitive components of behavior throughout lifespan in male and female C57BL/6 mice that were fed control-or rapamycin-supplemented chow. Our studies show that rapamycin enhances cognitive function in young adult mice and blocks age-associated cognitive decline in older animals. In addition, mice fed with rapamycin-supplemented chow showed decreased anxiety and depressive-like behavior at all ages tested. Levels of three major monoamines (norepinephrine, dopamine and 5-hydroxytryptamine) and their metabolites (3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindolacetic acid) were significantly augmented in midbrain of rapamycin-treated mice compared to controls."

According to the news editors, the research concluded: "Our results suggest that chronic, partial inhibition of mTOR by oral rapamycin enhances learning and memory in young adults, maintains memory in old C57BL/6J mice, and has concomitant anxiolytic and antidepressant-like effects, possibly by stimulating major monoamine pathways in brain."

For more information on this research see: Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience, 2012;223():102-13. (Elsevier - www.elsevier.com; Neuroscience - www.elsevier.com/wps/product/cws_home/468)

The news editors report that additional information may be obtained by contacting J. Halloran, Barshop Institute, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, United States. Additional authors for this research include S.A. Hussong, R. Burbank, N. Podlutskaya, K.E. Fischer, L.B. Sloane, S.N. Austad, R. Strong, A. Richardson, M.J. Hart and V. Galvan (see also Neuroscience).

Keywords for this news article include: Texas, Treatment, San Antonio, Neuroscience, United States, North and Central America.

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