By a News Reporter-Staff News Editor at Clinical Trials Week -- Data detailed on Immune System Diseases and Conditions have been presented. According to news originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Anaemia is prevalent among children born to HIV-positive women, and it is associated with adverse effects on cognitive and motor development, growth, and increased risks of morbidity and mortality. To examine the effect of daily multivitamin supplementation on haematologic status and mother-to-child transmission (MTCT) of HIV through breastfeeding."
Our news journalists obtained a quote from the research from the Harvard School of Public Health, "A total of 2387 infants born to HIV-positive women from Dar es Salaam, Tanzania were enrolled in a randomized, double-blind, placebo-controlled trial, and provided a daily oral supplement of multivitamins (vitamin B complex, C and E) or placebo at age 6 weeks for 24 months. Among them, 2008 infants provided blood samples and had haemoglobin concentrations measured at baseline and during a follow-up period. Anaemia was defined as haemoglobin concentrations <11 g/dL and severe anaemia <8.5 g/dL. Haemoglobin concentrations among children in the treatment group were significantly higher than those in the placebo group at 12 (9.77 vs. 9.64 g/dL, p=0.03), 18 (9.76 vs. 9.57 g/dL, p=0.004), and 24 months (9.93 vs. 9.75 g/dL, p=0.02) of follow-up. Compared to those in the placebo group, children in the treatment group had a 12% lower risk of anaemia (hazard ratio (HR): 0.88; 95% CI: 0.79-0.99; p=0.03). The treatment was associated with a 28% reduced risk of severe anaemia among children born to women without anaemia (HR: 0.72; 95% CI: 0.56-0.92; p=0.008), but not among those born to women with anaemia (HR: 1.10; 95% CI: 0.79-1.54; p=0.57; p for interaction=0.007). One thousand seven hundred fifty three infants who tested HIV-negative at baseline and had HIV testing during follow-up were included in the analysis for MTCT of HIV. No association was found between multivitamin supplements and MTCT of HIV. Multivitamin supplements improve haematologic status among children born to HIV-positive women."
According to the news editors, the research concluded: "Further trials focusing on anaemia among HIV-exposed children are warranted in the context of antiretroviral therapy."
For more information on this research see: Multivitamin supplementation improves haematologic status in children born to HIV-positive women in Tanzania. Journal of the International Aids Society, 2013;16(1):18022. (BioMed Central - www.biomedcentral.com/; Journal of the International Aids Society - www.jiasociety.org)
The news correspondents report that additional information may be obtained from E. Liu, Dept. of Global Health and Population, Harvard School of Public Health, Boston, MA 02120, United States. Additional authors for this research include C. Duggan, K.P. Manji, R. Kupka, S. Aboud, R.J. Bosch, R.R. Kisenge, J. Okuma and W.W Fawzi (see also Immune System Diseases and Conditions).
Keywords for this news article include: Boston, Therapy, HIV/AIDS, Placebos, Treatment, Pediatrics, RNA Viruses, Retroviridae, Massachusetts, United States, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Clinical Trials and Studies, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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