By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Antioxidants. According to news reporting out of Santiago, Chile, by NewsRx editors, research stated, "Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Major advances in the treatment of acute coronary syndromes and myocardial infarction, using cardiologic interventions, such as thrombolysis or percutaneous coronary angioplasty (PCA) have improved the clinical outcome of patients."
Our news journalists obtained a quote from the research from the University of Chile, "Nevertheless, as a consequence of these procedures, the ischemic zone is reperfused, giving rise to a lethal reperfusion event accompanied by increased production of reactive oxygen species (oxidative stress). These reactive species attack biomolecules such as lipids, DNA, and proteins enhancing the previously established tissue damage, as well as triggering cell death pathways. Studies on animal models of AMI suggest that lethal reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented. Although a number of strategies have been aimed at to ameliorate lethal reperfusion injury, up to date the beneficial effects in clinical settings have been disappointing. The use of antioxidant vitamins could be a suitable strategy with this purpose."
According to the news editors, the research concluded: "In this review, we propose a systematic approach to the molecular basis of the cardioprotective effect of antioxidant vitamins in myocardial ischemia-reperfusion injury that could offer a novel therapeutic opportunity against this oxidative tissue damage."
For more information on this research see: Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction. Biomed Research International, 2013;2013():437613 (see also Antioxidants).
Our news journalists report that additional information may be obtained by contacting R. Rodrigo, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile. Additional authors for this research include M. Libuy, F. Feliu and D. Hasson.
Keywords for this news article include: Antioxidants, Chile, Surgery, Santiago, Reperfusion, South America, Protective Agents, Cardiovascular Surgical Procedures.
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