By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Oncology. According to news originating from Perugia, Italy, by NewsRx correspondents, research stated, "Glyoxalase 1 is a scavenging enzyme of potent precursors in reactive oxygen species formation and is involved in the occurrence and progression of human malignancies. Glyoxalase I A111E polymorphism has been suggested to influence its enzymatic activity."
Our news journalists obtained a quote from the research from the University of Perugia, "The present study was aimed at investigating the association of this polymorphism with oxidative stress and its implications in prostate cancer progression or survival. The polymorphism was genotyped in human differently aggressive and invasive prostate cancer cell lines, in 571 prostate cancer or 588 benign prostatic hyperplasia patients, and 580 healthy subjects by Polymerase Chain Reaction/Restriction Fragment Length Polymorphism. Glyoxalase 1 activity, the pro-oxidant Glyoxalase 1-related Argpyrimidine and oxidative stress biomarkers were evaluated by biochemical analyses. Glyoxalase 1 polymorphism was associated with an increase in Glyoxalase 1-related pro-oxidant Argpyrimidine and oxidative stress levels and cancer progression. The mutant A allele conferred a modest risk of prostate cancer, a marked risk of prostate cancer progression and a lower survival time, compared to the wild C allele. The results of our exploratory study point out a significant role for Glyoxalase 1 in prostate cancer progression, providing an additional candidate for risk assessment in prostate cancer patients and an independent prognostic factor for survival."
According to the news editors, the research concluded: "Finally, we provided evidence of the biological plausibility of Glyoxalase 1 polymorphism, either alone or in combination with other ones, all related to oxidative stress control that represents a key event in PCa development and progression."
For more information on this research see: Glyoxalase 1-419C>A variant is associated with oxidative stress: implications in prostate cancer progression. Plos One, 2013;8(9):e74014. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news correspondents report that additional information may be obtained from C. Antognelli, Dept. of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy. Additional authors for this research include L. Mezzasoma, E. Mearini and V.N Talesa (see also Oncology).
Keywords for this news article include: Italy, Europe, Perugia, Genetics, Oncology, Risk and Prevention, Metastatic Prostate Cancer.
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