By a News Reporter-Staff News Editor at Blood Weekly -- New research on Aging Research is the subject of a report. According to news originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Aging is associated with loss of muscle mass and strength, reduced satellite cell number, and lower regenerative potential. Testosterone increases muscle mass, strength, and satellite cell number in humans; however, the effects of testosterone on the regenerative potential of skeletal muscle are unclear."
Our news journalists obtained a quote from the research from Boston Medical Center, "Here, we investigated the effect of testosterone on the skeletal muscle regeneration of young (2-month-old) and aged (24-month-old) male mice. We show that testosterone increases the number of proliferating satellite cells in regenerating 'tibialis anterior' muscle of young and aged castrated mice 2 and 4 days postinjury. Testosterone supplementation increases the number and the cross-sectional area of regenerating fibers in both classes of age 4 days postinjury. Testosterone increases satellite cell activation and proliferation and the regeneration of both young and aged mouse muscle."
According to the news editors, the research concluded: "These data suggest prospective application of androgens to improve the regenerating potential of the aged human skeletal muscle."
For more information on this research see: Testosterone improves the regeneration of old and young mouse skeletal muscle. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 2013;68(1):17-26 (see also Aging Research).
The news correspondents report that additional information may be obtained from C. Serra, Section of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston, MA 02118, United States. Additional authors for this research include F. Tangherlini, S. Rudy, D. Lee, G. Toraldo, N.L. Sandor, A. Zhang, R. Jasuja and S. Bhasin.
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Boston, Massachusetts, United States, Aging Research, Bioengineering, Muscle Regeneration, North and Central America.
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