By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on Diet and Nutrition Disorders is the subject of a report. According to news reporting from Belgrade, Serbia, by NewsRx journalists, research stated, "Rett syndrome (RTT) is a severe neurodevelopmental disorder. Bone manifestations of RI I include osteopenia and fractures."
The news correspondents obtained a quote from the research from the Institute of Epidemiology, "Studies addressing serum vitamin D levels in patients with RTT are scarce. The goals of this study were (1) to determine the prevalence of vitamin D deficiency in patients with RTT, (2) to compare serum vitamin D levels between patients with RTT and those with other neurological diseases, and (3) to explore the correlation between demographic and clinical characteristics of patients with RTT and vitamin D levels. Demographic and clinical characteristics included age, body mass index Z-score, mutation status, clinical severity score, presence of epilepsy, number of antiepileptic drugs, history of fractures, scoliosis, and ambulation ability. Laboratory parameters included serum 25-hydroxyvitamin D [25(OH)D], PTH, calcium, and alkaline phosphatase. The study included 35 patients with RTT and 35 age-matched females with other neurological diseases. The median serum 25(OH)D concentration in the RTT group was 26.25 nmol/L, with values <75 nmol/L in all participants. Severe deficiency (<25 nmol/L) was detected in 17 of 35 (48.6%) patients. The median 25(OH)D concentration was significantly lower in patients with RTT than in control subjects. The risk for fracture by 12 years of age in patients with RTT was 35.3%. An inverse correlation of the 25(OH)D level to age and PTH level was detected. Patients receiving antiepileptic polytherapy had a 3.3 times greater chance for severe vitamin D deficiency than patients receiving monotherapy. The prevalence of vitamin D deficiency in patients with RTT is higher than that in patients with other neurological diseases."
According to the news reporters, the research concluded: "The high risk for vitamin D deficiency should be accounted for in the strategy of antiepileptic treatment in RTT, especially when polytherapy is considered."
For more information on this research see: Vitamin D Deficiency in Serbian Patients With Rett Syndrome. Journal of Clinical Endocrinology & Metabolism, 2013;98(12):E1972-E1978. Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Soc, 8401 Connecticut Ave, Suite 900, Chevy Chase, MD 20815-5817, USA. (The Endocrine Society - www.endo-society.org/; Journal of Clinical Endocrinology & Metabolism - jcem.endojournals.org/)
Our news journalists report that additional information may be obtained by contacting A. Sarajlija, Inst Epidemiol, Belgrade, Serbia. Additional authors for this research include M. Djuric, D.K. Tepavcevic, S. Grkovic and M. Djordjevic (see also Diet and Nutrition Disorders).
Keywords for this news article include: Serbia, Europe, Belgrade, Avitaminosis, Malnutrition, Rett Syndrome, Deficiency Diseases, Vitamin D Deficiency, Nervous System Diseases, Neurologic Manifestations, Neurodegenerative Diseases, X-Linked Mental Retardation, Diet and Nutrition Disorders, Neurobehavioral Manifestations, Nutritional and Metabolic Diseases
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