By a News Reporter-Staff News Editor at Blood Weekly -- Fresh data on Hematologic Diseases are presented in a new report. According to news originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Whether folic acid fortification and supplementation at the population level have led to a higher prevalence of vitamin B-12 deficiency in the absence of anemia remains to be examined among a nationally representative sample of older U.S. adults. We assessed the prevalence of low vitamin B-12 status in the absence of anemia or macrocytosis before and after fortification among adults aged > 50 y using cross-sectional data from the NHANES 1991-1994 (prefortification) and 2001-2006 (postfortification)."
Our news journalists obtained a quote from the research from Center for Disease Control and Prevention, "We compared the prefortification and postfortification prevalence of multiple outcomes, including serum vitamin B-12 deficiency ( 100 fL) using multinomial logistic regression, adjusting for age, sex, ethnicity, body mass index, C-reactive protein, and vitamin B-12 supplement use. Prefortification and postfortification serum vitamin B-12 deficiency without anemia [4.0 vs. 3.9%; adjusted prevalence ratio (aPR) (95% Cl): 0.98 (0.67, 1.44)] or without macrocytosis [4.2 vs. 4.1%; aPR (95% Cl): 0.96 (0.65, 1.43)] remained unchanged. Marginal deficiency without anemia [25.1 vs. 20.7%; aPR (95% Cl): 0.82 (0.72, 0.95)] or without macrocytosis [25.9 vs. 21.3%; aPR (95% Cl): 0.82 (0.72, 0.94)] were both significantly lower after fortification. After fortification, higher folic acid intake was associated with a lower prevalence of low serum B-12 status in the absence of anemia or macrocytosis. Results suggest that the prevalence of low serum B-12 status in the absence of anemia or macrocytosis among older U.S. adults did not increase after fortification."
According to the news editors, the research concluded: "Thus, at the population level, we found no evidence to support concerns that folic acid adversely affected the clinical presentation of vitamin B-12 deficiency among older adults."
For more information on this research see: The Prevalence of Low Serum Vitamin B-12 Status in the Absence of Anemia or Macrocytosis Did Not Increase among Older US Adults after Mandatory Folic Acid Fortification. Journal of Nutrition, 2014;144(2):170-176. Journal of Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nutrition - www.hindawi.com/journals/jnume/)
The news correspondents report that additional information may be obtained from Y.P. Qi, Center Dis Control & Prevent, Div Sci Lab, Natl Center Environm Hlth, Atlanta, GA, United States. Additional authors for this research include A.N. Do, H.C. Hamner, C.M. Pfeiffer and R.J. Berry (see also Hematologic Diseases).
Keywords for this news article include: Anemia, Atlanta, Georgia, United States, Hematologic Diseases, North and Central America, Hemic and Lymphatic Diseases
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