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Does obesity during pregnancy impact the baby's chances of developing strong, healthy bones? No one knows for certain, but ongoing
In an early investigation,
Analysis of fetal bone cells from the skull and vertebrae suggests that changes in the functioning of a gene, HoxA10, may help explain this difference in early bone formation, according to Chen.
Studies by scientists elsewhere have already established that HoxA10 is important to bone formation and growth. But Chen's investigation, documented in a 2012 article in the
Chen and his team found that HoxA10 was downregulated as a result of high levels of DNA methylation, a biochemical process also referred to as gene methylation. If the results seen in rats hold true for humans, elevated DNA methylation of HoxA10 may increase the baby's risk of developing bone disease, such as osteoporosis, later in life.
The results also suggest that it is critical to start early in ensuring that a mother's nutrition benefits the developing child's bone health.
Chen collaborated with
Read more (http://www.ars.usda.gov/is/AR/archive/feb14/obesity0214.htm) about the research in the
ARS is the
TNS 30VianaGem - 140228-4652642 30VianaGem
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