By a News Reporter-Staff News Editor at AIDS Weekly -- Researchers detail new data in Immune System Diseases and Conditions. According to news reporting originating in New York City, New York, by NewsRx journalists, research stated, "An optimal vitamin D status may benefit liver transplantation (LT) patients. Higher levels of 25-hydroxyvitamin D [25(OH)D] mitigate steroid-induced bone loss after LT, correlate with better hepatitis C virus treatment responses, and increase graft survival."
The news reporters obtained a quote from the research from Mount Sinai Medical Center, "This study investigated 25(OH)D levels and assessed strategies for vitamin D deficiency prevention in human immunodeficiency virus (HIV)-positive patients with advanced liver disease who were enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study. 25(OH)D was measured in banked specimens from 154 LT candidates/recipients with the DiaSorin assay; deficiency was defined as a 25(OH)D level <20 ng/mL. Information about vitamin D supplement use after LT was obtained from medication logs and via surveys. Logistic regression, Cox regression, and linear repeated measures analyses were performed with SAS software. We found that none of the 17 academic medical centers in the United States routinely recommended vitamin D supplements before LT, and only a minority (4/17) recommended vitamin D supplements to all patients after LT. Seventy-one percent of the 139 patients with pre-LT values had vitamin D deficiency, which was significantly associated with cirrhosis (P=0.01) but no other variable. The vitamin D status improved modestly after LT; however, the status was deficient for 40% of the patients 1 year after LT. In a multivariate linear repeated measures model, a higher pre-LT 25(OH)D level (P <0.001), specimen collection in the summer (P <0.001), a routine vitamin D supplementation strategy after LT (P <0.001), and the time elapsing since LT (P=0.01) were significantly associated with increases in the post-LT 25(OH)D level; black race was associated with a decreased level (P=0.02)."
According to the news reporters, the research concluded: "The majority of patients awaiting LT were vitamin D deficient, and approximately half were vitamin D deficient after LT. More extensive use of vitamin D supplements, more sun exposure, or both are needed to prevent this deficiency in HIV-positive LT candidates and recipients. Liver Transpl 20:156-164, 2014."
For more information on this research see: Vitamin D Status of Human Immunodeficiency Virus-Positive Patients With Advanced Liver Disease Enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study. Liver Transplantation, 2014;20(2):156-164. Liver Transplantation can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Liver Transplantation - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1527-6473)
Our news correspondents report that additional information may be obtained by contacting A.D. Branch, Mt Sinai Med Center, Recanati Miller Transplant Inst, New York, NY 10029, United States. Additional authors for this research include B. Barin, A. Rahman, P. Stock and T.D. Schiano (see also Immune System Diseases and Conditions).
Keywords for this news article include: HIV/AIDS, Virology, RNA Viruses, Retroviridae, New York City, United States, HIV Infections, Liver Diseases, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Digestive System Diseases, Human Immunodeficiency Virus, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions
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