Clinical Trials Week
Elevated homocysteine, which may enhance exfoliation material formation, is one possible risk factor that has received significant research attention. Research studies demonstrate that high intake of vitamin B6, vitamin B12 and folate is associated with lower homocysteine levels. A prospective study from Massachusetts Eye and Ear, Brigham and
The researchers designed a prospective cohort study using more than 20 years of follow-up data from the Nurses' Health Study (all female registered nurses) and the Health Professionals Follow-up Study (all male health professionals) from
"We included a subset of 78,980 women and 41,221 men who were 40 years or older, free of glaucoma, had completed dietary questionnaires, and reported an eye examination during follow-up," said lead author
The results showed that vitamin B6 and B12 intake was not associated with EG/SEG risk in pooled analyses (P= .52 and P= .99 for linear trend, respectively). However, there was a trend of a reduced risk of EG/SEG with higher total folate intake, with relations being stronger for higher folate intake from supplements than from diet alone.
"Our conclusions are that higher folate intake is associated with a lower risk for EG/SEG, supporting a possible causal role of homocysteine in EG/SEG," said senior author
Keywords for this news article include: Homocysteine, Sulfur Amino Acids, Clinical Trials and Studies,
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