Daily News: Disease

Research Data from Mayo Clinic Update Understanding of Inflammation

Gastroenterology Week

06-13-14

By a News Reporter-Staff News Editor at Gastroenterology Week -- New research on Inflammation is the subject of a report. According to news reporting originating from Scottsdale, Arizona, by NewsRx correspondents, research stated, "Although epidemiologic and experimental evidence strongly implicates chronic inflammation and dietary fats as risk factors for cancer, the mechanisms underlying their contribution to carcinogenesis are poorly understood. Here we present genetic evidence demonstrating that deletion of peroxisome proliferator-activated receptor delta (PPAR delta) attenuates colonic inflammation and colitis-associated adenoma formation/growth."

Our news editors obtained a quote from the research from Mayo Clinic, "Importantly, PPAR delta is required for dextran sodium sulfate induction of proinflammatory mediators, including chemokines, cytokines, COX-2, and prostaglandin E-2 (PGE(2)), in vivo. We further show that activation of PPAR delta induces COX-2 expression in colonic epithelial cells. COX-2-derived PGE(2) stimulates macrophages to produce proinflammatory chemokines and cytokines that are responsible for recruitment of leukocytes from the circulation to local sites of inflammation."

According to the news editors, the research concluded: "Our results suggest that PPAR delta promotes colonic inflammation and colitis-associated tumor growth via the COX-2-derived PGE(2) signaling axis that mediates cross-talk between tumor epithelial cells and macrophages."

For more information on this research see: Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(19):7084-7089. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)

The news editors report that additional information may be obtained by contacting D.Z. Wang, Mayo Clinic, Div Gastroenterol, Scottsdale, AZ 85259, United States. Additional authors for this research include L.C. Fu, W. Ning, L.X. Guo, X.F. Sun, S.K. Dey, R. Chaturvedi, K.T. Wilson and R.N. DuBois (see also Inflammation).

Keywords for this news article include: Arizona, Scottsdale, Immunology, Organelles, PPAR delta, Macrophages, Microbodies, Inflammation, United States, Membrane Proteins, Cytokine Receptors, Chemokine Receptors, Intracellular Space, Cytoplasmic Vesicles, DNA-Binding Proteins, Transcription Factors, Cytoplasmic Structures, North and Central America

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