Daily News: Aging

Study Results from University of Macau Broaden Understanding of Peptides and Proteins

Life Science Weekly

06-20-14

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating in Macao, People's Republic of China, by NewsRx journalists, research stated, "The standard extract of Ginkgo biloba leaves (EGb761) is used clinically in Europe for the symptomatic treatment of impaired cerebral function in primary degenerative dementia syndromes, and the results of numerous in vivo and in vitro studies have supported such clinical use. The abnormal production and aggregation of amyloid beta peptide (A beta) and the deposition of fibrils in the brain are regarded as key steps in the onset of Alzheimer's Disease (AD), and the inhibition of A beta aggregation and destabilization of the preformed fibrils represent viable approaches for the prevention and treatment of AD."

The news reporters obtained a quote from the research from the University of Macau, "Flavonoid glycosides and terpene trilactones (TTLs) are the two main components of EGb761 which represent 24 and 6% of the overall content, respectively. In our research, seven abundant flavonoid glycosides 1-7 were isolated from the extract of Ginkgo biloba leaves and characterized by spectroscopic analysis. Furthermore, an ultra-high performance liquid chromatography method was established for the simultaneous quantification of these seven flavonoids. The inhibitory activities of these flavonoids, as well as four TTLs, i.e., ginkgolides A, B, and C and bilobalide (compounds 8-11), were evaluated towards A beta 42 fibril formation using a thioflavin T fluorescence assay. It was found that three flavonoids 1, 3 and 4 exhibited moderate inhibitory activities, whereas the other four flavonoids 2, 5, 6 and 7, as well as the four terpene trilactones, showed poor activity."

According to the news reporters, the research concluded: "This is the first report of the inhibition of A beta fibril formation of two characteristic acylated flavonoid glycosides 6, 7 in Ginkgo leaves, on the basis of which the structure-activity relationship of these flavonoids 1-7 was discussed."

For more information on this research see: Quantitative Analysis of the Flavonoid Glycosides and Terpene Trilactones in the Extract of Ginkgo biloba and Evaluation of Their Inhibitory Activity towards Fibril Formation of beta-Amyloid Peptide. Molecules, 2014;19(4):4466-4478. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

Our news correspondents report that additional information may be obtained by contacting H.Y. Xie, Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macao, People's Republic of China. Additional authors for this research include J.R. Wang, L.F. Yau, Y. Liu, L. Liu, Q.B. Han, Z.Z. Zhao and Z.H. Jiang (see also Proteins).

Keywords for this news article include: Asia, Macao, Amyloid, Proteins, People's Republic of China

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