Investigators from University of South Carolina Report New Data on Diet and Nutrition (Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in Mice)
By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Health and Medicine. According to news originating from Columbia, South Carolina, by NewsRx correspondents, research stated, "Although there are currently no approved treatments for cancer cachexia, there is an intensified interest in developing therapies because of the high mortality index associated with muscle wasting diseases. Successful treatment of the cachectic patient focuses on improving or maintaining body weight and musculoskeletal function."
Our news journalists obtained a quote from the research from the University of South Carolina, "Nutraceutical compounds, including the natural phytochemical quercetin, are being examined as potential treatments because of their anti-inflammatory, antioxidant, and anticarcinogenic properties. The purpose of this study was to determine the effect of quercetin supplementation on the progression of cachexia in the adenomatous polyposis coli (Apc)(Min/+) mouse model of colorectal cancer. At 15 wk of age, C57BL/6 and male Apc(Min+) mice were supplemented with 25 mg/kg of quercetin or vehicle solution mix of Tang juice and water (V) daily for 3 wk. Body weight, strength, neuromuscular performance, and fatigue were assessed before and after quercetin or V interventions. Indicators of metabolic dysfunction and inflammatory signaling were also assessed. During the treatment period, the relative decrease in body weight in the Apc(Min/+) mice gavaged with V (Apc(Min/+)V; -14% +/- 2.3) was higher than in control mice gavaged with V (+0.6% +/- 1.0), control mice gavaged with quercetin (-2% +/- 1.0), and Apc(Min/+) mice gavaged with quercetin (Apc(Min/+)Q; -9% +/- 1.3). At 18 wk of age, the loss of grip strength and muscle mass shown in Apc(Min/+)V mice was significantly attenuated (P < 0.05) in Apc(Min/+)Q mice. Furthermore, Apc(Min+)V mice had an induction of plasma interleukin-6 and muscle signal transducer and activator of transcription 3 phosphorylation, which were significantly (P < 0.05) mitigated in Apc(Min/+)Q mice, despite having a similar tumor burden: Quercetin treatment did not improve treadmill run-time-to-fatigue, hyperglycemia, or hyperlipidemia in cachectic Apc(Min/+) mice."
According to the news editors, the research concluded: "Overall, quercetin supplementation positively affected several aspects of cachexia progression in mice and warrants further exploration as a potential anticachectic therapeutic."
For more information on this research see: Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in Mice. Journal of Nutrition, 2014;144(6):868-875. Journal of Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nutrition - www.hindawi.com/journals/jnume/)
The news correspondents report that additional information may be obtained from K.T. Velazquez, University of South Carolina, Sch Med, Dept. of Pathol Microbiol & Immunol, Columbia, SC, United States. Additional authors for this research include R.T. Enos, A.A. Narsale, M.J. Puppa, J.M. Davis, E.A. Murphy and J.A. Carson (see also Health and Medicine).
Keywords for this news article include: Cancer, Columbia, Oncology, United States, South Carolina, Health and Medicine, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC