Daily News: Aging

Studies from University of Colorado in the Area of Menopause Reported (Oxidative stress contributes to large elastic arterial stiffening across the...

Women's Health Weekly

07-11-14

Studies from University of Colorado in the Area of Menopause Reported (Oxidative stress contributes to large elastic arterial stiffening across the stages of the menopausal transition)

By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators discuss new findings in Menopause. According to news reporting from Aurora, Colorado, by NewsRx journalists, research stated, "It is unclear how changes in ovarian hormones during the menopausal transition contribute to age-associated arterial stiffening. We sought to evaluate differences in arterial stiffness and the role of oxidative stress across the stages of the menopausal transition in healthy women."

The news correspondents obtained a quote from the research from the University of Colorado, "Arterial stiffness (carotid artery compliance and ultrasound) was measured during immediate infusions of saline (control) and ascorbic acid (experimental model to immediately decrease oxidative stress) in 97 healthy women (22-70 y) classified as premenopausal (n = 24; mean [SD] age, 33 [7] y), early perimenopausal (n = 21; 49 [3] y) or late perimenopausal (n = 21; 50 [4] y), or postmenopausal (n = 31; 57 [5] y). Basal carotid artery compliance was different among the groups (P < 0.001). Mean [SD] compliance was highest in premenopausal women (1.31 [0.25] mm(2)/mm Hg x 10(-1)), with progressive decrements in perimenopausal (early perimenopausal, 0.98 [0.31] mm(2)/mm Hg x 10(-1); late perimenopausal, 0.90 [0.25] mm(2)/mm Hg x 10(-1)) and postmenopausal (0.75 [0.24] mm(2)/mm Hg x 10(-1)) women. Ascorbic acid infusion improved compliance in late perimenopausal (15% [18%] increase, P = 0.001) and postmenopausal (17% [26%] increase, P = 0.002) women but not in early perimenopausal or premenopausal women. Arterial stiffening worsens across the stages of the menopausal transition in healthy women. This seems to be mediated, in part, by oxidative stress, particularly during the late perimenopausal and postmenopausal periods."

According to the news reporters, the research concluded: "It remains uncertain whether this is specifically caused by loss of ovarian function or aging."

For more information on this research see: Oxidative stress contributes to large elastic arterial stiffening across the stages of the menopausal transition. Menopause-The Journal of the North American Menopause Society, 2014;21(6):624-632. Menopause-The Journal of the North American Menopause Society can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Menopause).

Our news journalists report that additional information may be obtained by contacting K.L. Hildreth, University of Colorado, Sch Med, Dept. of Med, Div Geriatr Med, Aurora, CO, United States. Additional authors for this research include W.M. Kohrt and K.L. Moreau.

Keywords for this news article include: Aurora, Colorado, Genetics, Angiology, Menopause, Gynecology, United States, Women's Health, North and Central America

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