Findings from Kyung Hee University Reveals New Findings on Dementia (6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia)
By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Researchers detail new data in Dementia and Mental Illness. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, "Recently, increased attention has been directed towards medicinal extracts as potential new drug candidates for dementia. Ginger has long been used as an important ingredient in cooking and traditional herbal medicine."
The news correspondents obtained a quote from the research from Kyung Hee University, "In particular, ginger has been known to have disease-modifying effects in Alzheimer's disease (AD). However, there is no evidence of which constituents of ginger exhibit therapeutic effects against AD. A growing number of experimental studies suggest that 6-shogaol, a bioactive component of ginger, may play an important role as a memory-enhancing and anti-oxidant agent against neurological diseases. 6-Shogaol has also recently been shown to have anti-neuroinflammatory effects in lipopolysaccharide (LPS)-treated astrocytes and animal models of Parkinson's disease, LPS-induced inflammation and transient global ischemia. However, it is still unknown whether 6-shogaol has anti-inflammatory effects against oligomeric forms of the A beta (A beta O) in animal brains. Furthermore, the effects of 6-shogaol against memory impairment in dementia models are also yet to be investigated. In this study, we found that administration of 6-shogaol significantly reduced microgliosis and astrogliosis in intrahippocampal A beta O-injected mice, ameliorated A beta O and scopolamine-induced memory impairment, and elevated NGF levels and pre- and post-synaptic marker in the hippocampus."
According to the news reporters, the research concluded: "All these results suggest that 6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia."
For more information on this research see: 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochemical and Biophysical Research Communications, 2014;449(1):8-13. Biochemical and Biophysical Research Communications can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Biochemical and Biophysical Research Communications - www.elsevier.com/wps/product/cws_home/622790)
Our news journalists report that additional information may be obtained by contacting M. Moon, Kyung Hee Univ, Kyung Hee East West Pharmaceut Res Inst, Seoul 130701, South Korea. Additional authors for this research include H.G. Kim, J.G. Choi, H. Oh, P.K.J. Lee, S.K. Ha, S.Y. Kim, Y. Park, Y. Huh and M.S. Oh (see also Dementia and Mental Illness).
Keywords for this news article include: Seoul, South Korea, Asia, Central Nervous System Diseases, Dementia, Dementia and Mental Illness, Neuroinflammation
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