Investigators from Vanderbilt University Have Reported New Data on Chondroitin Sulfate (Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation)
By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Chondroitin Sulfate is now available. According to news reporting from Nashville, Tennessee, by NewsRx journalists, research stated, "Glucosamine and chondroitin supplements have been shown to have anti-inflammatory properties in both in vitro studies and animal models; however, little is known about these relationships in humans. The VITamins and Lifestyle (VITAL) biomarker study evaluated the associations between use of these supplements and a panel of circulating inflammatory biomarkers."
The news correspondents obtained a quote from the research from Vanderbilt University, "Study participants included 217 men and women age 50-75 years living in the Seattle metropolitan area. Use of glucosamine and chondroitin supplements was ascertained by home interview/supplement inventory. Inflammation was assessed by using blood and urine collected at the time of home interview. Measures of systemic inflammation included plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1 beta, IL6, IL-8, tumor necrosis factor (TNF)-alpha, soluble TNF receptors I and II, and urinary prostaglandin E-2-metabolite (PGE-M). Multivariate-adjusted linear regression was used to evaluate the associations between supplement use and biomarkers of inflammation. High users (14 or more pills/week) of chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI], 0.39-1.04; p for trend = .03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98; p for trend = .07) than nonusers. Compared with nonusers, high users of glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for trend = .09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for trend = 0.10). Use of glucosamine and chondroitin supplements was not associated with the other markers of inflammation."
According to the news reporters, the research concluded: "These results support prior research suggesting that use of glucosamine and chondroitin is associated with reduced hsCRP and PGE(2), but further work is needed to more definitively evaluate the anti-inflammatory potential of these supplements."
For more information on this research see: Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation. Journal of Alternative and Complementary Medicine, 2014;20(6):479-485. Journal of Alternative and Complementary Medicine can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Journal of Alternative and Complementary Medicine - www.liebertpub.com/overview/journal-of-alternative-and-complementary-medicine-the/26/)
Our news journalists report that additional information may be obtained by contacting E.D. Kantor, Vanderbilt University, Sch Med, Div Clin Pharmacol, Nashville, TN 37212, United States. Additional authors for this research include J.W. Lampe, S.L. Navarro, X.L. Song, G.L. Milne and E. White (see also Chondroitin Sulfate).
Keywords for this news article include: Nashville, Tennessee, Inflammation, United States, Diet and Nutrition, Chondroitin Sulfate, North and Central America
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