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Immunosuppressive drugs called thiopurines have been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, a rare bone marrow disorder, seven-fold among inflammatory bowel disease (IBD) patients. These data were reported in a new study1 (http://www.cghjournal.org/article/S1542-3565(14)00311-5/abstract) published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the
Thiopurines are an established treatment for IBD patients, used to reduce inflammation and provide symptom relief.
"In order to make appropriate, informed decisions about thiopurines, patients and providers need to be well-educated about the risks and benefits of this treatment," said study author Laurent Peyrin-Biroulet, MD, PhD, department of hepato-gastroenterology,
Researchers conducted a prospective observational study to determine the trends of IBD patients exposed to thiopurines. The researchers studied 19,486 patients enrolled in the Cancers Et Surrisque Associe aux Maladies inflammatoires intestinales
After three years of follow up, five patients were diagnosed with incident myeloid disorders. Four of these patients had been previously exposed to thiopurines. Patients who were not receiving thiopurines during the study and those who never received these drugs did not have an increased risk of myeloid disorders.
While these findings provide strong evidence of the connection between thiopurines and myeloid disorders in IBD patients, the absolute risk to an individual patient is only 1 in 10,000. The link between IBD patients receiving thiopurines and myeloid disorders remains complex. Physicians need to balance this risk against the known benefits of thiopurines in the management of IBD.
AGA has developed a guideline-based clinical decision support tool (http://campaigns.gastro.org/algorithms/crohns/) to help providers determine when to use thiopurines in the management of patients with inflammatory bowel disease.
IBD can negatively impact an individual's life and result in a significant amount of medical bills. Treatments for IBD vary and your doctor can discuss the following options with you: nutrition, emotional support, medical therapy and surgery. Learn more about IBD in AGA's patient brochure (http://www.gastro.org/patient-center/digestive-conditions/inflammatory-bowel-disease#Treatment%20for%20IBD).
1Lopez et al. Increased Risk of Acute Myeloid Leukemias and Myelodysplastic Syndromes in Patients Who Received Thiopurine Treatment for Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology 2014: 12(8) 1324-1329.
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