Findings from Pennsylvania State University Broaden Understanding of Malaria (Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response)
By a News Reporter-Staff News Editor at Malaria Weekly -- Investigators discuss new findings in Mosquito-Borne Diseases. According to news originating from University Park, Pennsylvania, by NewsRx correspondents, research stated, "In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration of leukocytes and parasite-infected RBCs in the brain. In this study, we explored the effect of vitamin D (VD; cholecalciferol) treatment on host immunity and outcome of ECM in C57BL/6 mice during Plasmodium berghei ANKA (PbA) infection."
Our news journalists obtained a quote from the research from Pennsylvania State University, "We observed that oral administration of VD both before and after PbA infection completely protected mice from ECM. VD administration significantly dampened the inducible systemic inflammatory responses with reduced circulating cytokines IFN-gamma and TNF and decreased expression of these cytokines by the spleen cells. Meanwhile, VD also resulted in decreased expression of the chemokines CXCL9 and CXCL10 and cytoadhesion molecules (ICAM-1, VCAM-1, and CD36) in the brain, leading to reduced accumulation of pathogenic T cells in the brain and ultimately substantial improvement of the blood brain barriers of PbA-infected mice. In addition, VD inhibited the differentiation, activation, and maturation of splenic dendritic cells. Meanwhile, regulatory T cells and IL-10 expression levels were upregulated upon VD treatment."
According to the news editors, the research concluded: "These data collectively demonstrated the suppressive function of VD on host inflammatory responses, which provides significant survival benefits in the murine ECM model."
For more information on this research see: Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response. Journal of Immunology, 2014;193(4):1314-1323. Journal of Immunology can be contacted at: Amer Assoc Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. (The American Association of Immunologists - www.aai.org; Journal of Immunology - www.jimmunol.org)
The news correspondents report that additional information may be obtained from X.Y. He, Pennsylvania State University, Dept. of Vet & Biomed Sci, University Park, PA 16802, United States. Additional authors for this research include J. Yan, X.T. Zhu, Q.H. Wang, W. Pang, Z.M. Qi, M.L. Wang, E.J. Luo, D.M. Parker, M.T. Cantorna, L.W. Cui and Y.M. Cao (see also Mosquito-Borne Diseases).
Keywords for this news article include: Malaria, Pennsylvania, United States, University Park, Protozoan Infections, Mosquito-Borne Diseases, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC