Daily News: Disease

New Findings in the Area of Inflammation Reported from B.L. Brucher and Colleagues (Epistemology of the origin of cancer: a new paradigm)

Cancer Weekly

08-22-14

By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Inflammation. According to news originating from Munich, Germany, by NewsRx correspondents, research stated, "Carcinogenesis is widely thought to originate from somatic mutations and an inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of metastasis. Fewer than 10% of all cancers are hereditary; the ratio in gastric (1%), colorectal (3-5%) and breast (8%) cancers is even less."

Our news journalists obtained a quote from the research, "Cancers caused by infection are thought to constitute some 15% of the non-hereditary cancers. Those remaining, 70 to 80%, are called 'sporadic,' because they are essentially of unknown etiology. We propose a new paradigm for the origin of the majority of cancers. Our paradigm postulates that cancer originates following a sequence of events that include (1) a pathogenic stimulus (biological or chemical) followed by (2) chronic inflammation, from which develops (3) fibrosis with associated changes in the cellular microenvironment. From these changes a (4) pre-cancerous niche develops, which triggers the deployment of (5) a chronic stress escape strategy, and when this fails to resolve, (6) a transition of a normal cell to a cancer cell occurs. If we are correct, this paradigm would suggest that the majority of the findings in cancer genetics so far reported are either late events or are epiphenomena that occur after the appearance of the pre-cancerous niche. If, based on experimental and clinical findings presented here, this hypothesis is plausible, then the majority of findings in the genetics of cancer so far reported in the literature are late events or epiphenomena that could have occurred after the development of a PCN. Our model would make clear the need to establish preventive measures long before a cancer becomes clinically apparent. Future research should focus on the intermediate steps of our proposed sequence of events, which will enhance our understanding of the nature of carcinogenesis. Findings on inflammation and fibrosis would be given their warranted importance, with research in anticancer therapies focusing on suppressing the PCN state with very early intervention to detect and quantify any subclinical inflammatory change and to treat all levels of chronic inflammation and prevent fibrotic changes, and so avoid the transition from a normal cell to a cancer cell."

According to the news editors, the research concluded: "The paradigm proposed here, if proven, spells out a sequence of steps, one or more of which could be interdicted or modulated early in carcinogenesis to prevent or, at a minimum, slow down the progression of many cancers."

For more information on this research see: Epistemology of the origin of cancer: a new paradigm. Bmc Cancer, 2014;14():331. Bmc Cancer can be contacted at: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England. (BioMed Central - www.biomedcentral.com/; Bmc Cancer - www.biomedcentral.com/bmccancer/)

The news correspondents report that additional information may be obtained from B.L. Brucher, Theodor-Billroth-Academy®, Munich, Germany (see also Inflammation).

The publisher's contact information for the journal Bmc Cancer is: Biomed Central LTD, Middlesex House, 34-42 Cleveland St, London W1T 4LB, England.

Keywords for this news article include: Munich, Europe, Cancer, Germany, Genetics, Oncology, Inflammation, Carcinogenesis.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.