Findings on Obesity Reported by Investigators at Yonsei University (Antihyperglycemic and Anti-Inflammatory Effects of Standardized Curcuma xanthorrhiza Roxb. Extract and Its Active Compound Xanthorrhizol in High-Fat Diet-Induced Obese Mice)
By a News Reporter-Staff News Editor at Obesity & Diabetes Week -- Investigators publish new report on Diet and Nutrition Disorders. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Xanthorrhizol, a natural compound isolated from Curcuma xanthorrhiza Roxb. (Java turmeric), has been reported to possess antioxidant and anticancer properties; however, its effects on metabolic disorders remain unknown. The aim of the present study was to evaluate the effects of xanthorrhizol (XAN) and C. xanthorrhiza extract (CXE) with standardized XAN on hyperglycemia and inflammatory markers in high-fat diet- (HFD-) induced obese mice."
Our news editors obtained a quote from the research from Yonsei University, "Treatment with XAN (10 or 25 mg/kg/day) or CXE (50 or 100 mg/kg/day) significantly decreased fasting and postprandial blood glucose levels in HFD-induced obese mice. XAN and CXE treatments also lowered insulin, glucose, free fatty acid (FFA), and triglyceride (TG) levels in serum. Epididymal fat pad and adipocyte size were decreased by high doses of XAN (26.6% and 20.1%) and CXE (25.8% and 22.5%), respectively. XAN and CXE treatment also suppressed the development of fatty liver by decreasing liver fat accumulation. Moreover, XAN and CXE significantly inhibited production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), and C-reactive protein (CRP) in adipose tissue (27.8-82.7%), liver (43.9-84.7%), and muscle (65.2-92.5%)."
According to the news editors, the research concluded: "Overall, these results suggest that XAN and CXE, with their antihyperglycemic and anti-inflammatory activities, might be used as potent antidiabetic agents for the treatment of type 2 diabetes."
For more information on this research see: Antihyperglycemic and Anti-Inflammatory Effects of Standardized Curcuma xanthorrhiza Roxb. Extract and Its Active Compound Xanthorrhizol in High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine, 2014;():1-10. Evidence-Based Complementary and Alternative Medicine can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Evidence-Based Complementary and Alternative Medicine - www.hindawi.com/journals/ecam/)
The news editors report that additional information may be obtained by contacting M.B. Kim, Yonsei University, Dept. of Biotechnol, Coll Life Sci & Biotechnol, Seoul 120749, South Korea. Additional authors for this research include C. Kim, Y. Song and J.K. Hwang (see also Diet and Nutrition Disorders).
Keywords for this news article include: Asia, Seoul, Obesity, Diabetes, Bariatrics, South Korea, Diet and Nutrition Disorders
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