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Even the most careful chosen meal can contain surprises. To defend against infectious microbes, viruses or other potential hazards that find their way to the intestines, a dedicated contingent of immune cells keeps watch within the thin layer of tissue that divides the contents of the gut from the body itself.
New research at
"IELs can originate directly from an organ known as the thymus, or they are induced from other, fully mature lymphocytes. Our research has uncovered the pathway necessary for the generation of both so-called natural and induced IELs," says study author
IELs police the single-cell layer of intestinal epithelium, a fine boundary that spans as much as 400 square meters and allows nutrients in and wastes out. Nearly all IELs belong to a group of lymphocytes (themselves a type of white blood cell) known as T cells, produced by the thymus, an organ below the breastbone.
IELs are made one of two ways. "Natural" IELs require no additional activation after they are produced by the thymus. "Induced" IELs, meanwhile, are produced when two types of mature T cells, CD4 and CD8 cells, acquire new traits and move into the gut epithelium, becoming IELs.
During an immune response, CD4 cells send out signals to other immune cells, earning them the name helper T cells. In research published last year, Mucida and his colleagues uncovered how CD4 cells lose much of their helper function, and take on characteristics more commonly associated with CD8 cells and IELs, which are less likely to promote inflammation.
The new research took a closer look at this pathway, which the team had since determined leads to all IELs, natural and induced. They focused on two proteins, T-bet and Runx3, transcription factors that regulate the expression of genes. Both T-bet and Runx3 occur in high levels in IELs, and were already known to play a role in the development and function of T cells.
"Using genetically modified mice, along with other techniques, we determined the hierarchy between these two transcription factors: T-bet induces the expression of Runx3," says
While these IELs, and the pathway leading to them, are crucial to intestinal health, they can sometimes malfunction and contribute to disease. For example, an unbalanced IEL response to gluten may lead to celiac disease, and reduced IEL function can also leave the intestine more vulnerable to infection.
"Now that we understand the IEL pathway and the genes involved, we can design studies that explore in more detail both IELs physiological, protective function and their detrimental side," Mucida says.
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