New Findings on Cholestasis from University of Salento Summarized (Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis)
By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Digestive System Diseases and Conditions. According to news reporting originating from Lecce, Italy, by NewsRx correspondents, research stated, "The accumulation of toxic hydrophobic bile acids in hepatocytes, observed during chronic cholestasis, induces substantial modification in the redox state and in mitochondrial functions. Recent reports have suggested a significant role of impaired lipid metabolism in the progression of chronic cholestasis."
Our news editors obtained a quote from the research from the University of Salento, "In this work we report that changes observed in the expression of the lipogenic enzymes acetyl-CoA carboxylase and fatty acid synthase were associated with a decrease in the activity of citrate carrier (CC), a protein of the inner mitochondrial membrane closely related to hepatic lipogenesis. We also verified that the impairment of citrate transport was dependent on modification of the phospholipid composition of the mitochondrial membrane and on cardiolipin oxidation. Silybin, an extract of silymarin with antioxidant and anti-inflammatory properties, prevented mitochondrial reactive oxygen species (ROS) production, cardiolipin oxidation, and CIC failure in cirrhotic livers but did not affect the expression of lipogenic enzymes. Moreover, supplementation of silybin was also associated with mitochondrial biogenesis."
According to the news editors, the research concluded: "We demonstrate that chronic cholestasis induces cardiolipin oxidation that in turn impairs mitochondrial function and further promotes ROS production. The capacity of silybin to limit mitochondrial failure is part of its hepatoprotective property."
For more information on this research see: Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis. Free Radical Biology and Medicine, 2014;73():117-126. Free Radical Biology and Medicine can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Free Radical Biology and Medicine - www.elsevier.com/wps/product/cws_home/525469)
The news editors report that additional information may be obtained by contacting G. Serviddio, Univ Salento, Dept. of Biol & Environm Sci & Technol, Lab Biochem & Mol Biol, I-73100 Lecce, Italy. Additional authors for this research include F. Bellanti, E. Stanca, P. Lunetti, M. Blonda, R. Tamborra, L. Siculella, G. Vendemiale, L. Capobianco and A.M. Giudetti (see also Digestive System Diseases and Conditions).
Keywords for this news article include: Antioxidants, Lecce, Italy, Europe, Haptens, Hepatology, Immunology, Cholestasis, Cardiolipins, Gastroenterology, Biliary Cirrhosis, Protective Agents, Digestive System Diseases and Conditions
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