Study Data from University of Bari Update Knowledge of Carcinogenesis [Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in Apc(Min/+) mice]
By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology is the subject of a report. According to news reporting originating from Bari, Italy, by NewsRx correspondents, research stated, "The promotion and progression of carcinogenesis are susceptible to nutritional interventions aimed at counteracting cancer development. Lipid metabolism is essential in the onset and progression of tumors and for cancer cell survival."
Our news editors obtained a quote from the research from the University of Bari, "In this study, we tested the effects of diets enriched with natural compounds, such as olive oil and salmon oil, in mice that spontaneously develop intestinal polyps (Apc(Min/+) mice). For this purpose, we evaluated polyp number and volume, intestinal mucosa proliferation/apoptosis, estrogen receptors (ERs) expression, fatty acid synthase and 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase gene expression and enzymatic activity. Compared with the standard diet, the salmon oil-enriched diet, containing a high percentage of omega-3 polyunsaturated fatty acids, and, to a lesser extent, olive oil-enriched diet reduced polyp number and volume through a reduction of proliferation and a marked proapoptotic effect. These biological effects were mediated by an inhibition of fatty acid synthase and HMGCoA reductase gene expression and activity and an increase of ER beta/ER alpha ratio."
According to the news editors, the research concluded: "Our findings suggest that a proper dietary lifestyle could contribute to primary cancer prevention."
For more information on this research see: Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in Apc(Min/+) mice. Carcinogenesis, 2014;35(7):1613-1619. Carcinogenesis can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Carcinogenesis - carcin.oxfordjournals.org)
The news editors report that additional information may be obtained by contacting M. Barone, University of Bari, Dept. of Emergency & Organ Transplantat DETO, Gastroenterol Unit, I-70124 Bari, Italy. Additional authors for this research include M. Notarnicola, M.G. Caruso, M.P. Scavo, M.T. Viggiani, V. Tutino, L. Polimeno, B. Pesetti, A. Di Leo and A. Francavilla (see also Oncology).
Keywords for this news article include: Bari, Italy, Europe, Cancer, Oncology, Synthase, Enzymes and Coenzymes
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