Aging causes damage to proteins such as carbonylation (protein oxi-dation) and glycation (protein-sugar cross-linking). Aging also causes mitochondrial energy to diminish and low level systemic inflammatory reactions to become pronounced. In addition, aging can cause imbalances in levels of blood glucose, resulting in systemic bodily damage.65-72
ChronoForte is a multi-nutrient combination designed to help protect against age-related processes. Carnosine is a multifunctional dipeptide made up of a chemical combination of the amino acids beta-alanine and L-histidine. It is found both in food and in the human body. Carnosine interferes with the destructive mechanisms of glycation, thus keeping protein healthy.73-76
L-carnitine is an amino acid that helps to maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria, where these fats are oxidized to produce the cellular energy ATP.* Acetyl-L-carnitine is the acetyl ester of the amino acid L-carnitine and is absorbed into the bloodstream slightly more efficiently than L-carnitine. However, both easily pass through cell membranes, and are utilized efficiently in the mitochondria.77,78
Alpha-lipoic acid is a fat- and water-soluble antioxidant with broad health-promoting benefits. In combination with acetyl-l-carnitine, alpha-lipoic acid can help maintain mitochondrial function, resulting in improved cellular energy.79-82
Alpha-lipoic acid is also a key enzymatic energy co-factor and can boost levels of glutathione, the body’s natural antioxidant.83-85
The herbal extract, nettle leaf, helps to maintain normal levels of TNF-a, IL-1B, and IL-6 believed to contribute to the destructive cascade that can affect almost every system in the body, including a healthy immune system.86,87*
Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) that helps prevent glucose from reacting with proteins that can lead to detrimental advanced glycation end products (AGEs) and helps counteracts glucose toxicity effects on the endothelial lining of the blood vessels, retina, and kidneys.88-90 The flavonoid, quercetin, an antioxidant, helps to maintain a normal balance of nuclear factor kappa B and stabilizes mast cells.91-96
Quercetin helps promote healthy blood flow and blocks the accumulation of the carbohydrate and sorbitol that can lead to neural tissue damage.97-99* The ingredients in ChronoForte provide synergistic action against the destructive age-related processes. |