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Alpha-lipoic acid consists of two different forms (isomers) that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect. The “S” form is produced from chemical manufacture and is not very biologically active. Alpha-lipoic acid supplements consist of the “R” and “S” form in a 50/50 ratio. That means a 100 mg alpha-lipoic acid supplement is providing 50 mg of the biologically active “R” form.

The human body normally produces and uses R-lipoic acid, the active form. R-lipoic acid significantly supports healthy inflammatory response, is a potent free-radical scavenger and has been shown to be more potent than the combined “R” and “S” form that comprises alpha-lipoic acid.38-47*

When alpha-lipoic acid is ingested, it is first converted to its reduced form, R-dihydro-lipoic acid, where the main action of lipoic acid is initiated. R-dihydro-lipoic acid is the reduced (or active) form of R-lipoic acid. By consuming R-dihydro-lipoic acid, you are obtaining the form of R-lipoic acid that is immediately available to cells. R-dihydro-lipoic acid (DHLA) protects the biomembranes and mitochondria from oxidative stresses of various kinds. While both alpha-lipoic acid and R-dihydro-lipoic acid effectively scavenge a number of radical species (hydroxyl radicals, nitric oxide radicals, peroxynitrite, hydrogen peroxide, and hypochlorite), only R-dihydro-lipoic acid has been shown effective against superoxide and peroxyl reactive oxygen species.48 R-dihydro-lipoic acid promotes healthy endothelial function, which may contribute to the regulation of blood pressure and vascular tone.49*

If you have diabetes or hypoglycemia, please consult your healthcare practitioner before supplementing with lipoic acid.

Diabetes, Blood Sugar, Antioxidant