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As people age, systemic inflammation can inflict degenerative effects throughout the body.1-5 A primary cause of this destructive cascade is the production of cell-signaling chemicals known as inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins also contribute to inflammatory processes.

Essential fatty acids (EFAs)
The body needs fatty acids to survive and is able to make all but two of them: linoleic acid (LA), in the omega-6 family and alphalinolenic acid (ALA), in the omega-3 family. These two fatty acids must be supplied by the diet and are therefore considered essential fatty acids (EFAs). Omega-3 fatty acids, found in cold-water fish (and fish oil), and perilla and flaxseed oils, can be part of a healthy diet. Omega-3 oils contain the essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are usually lacking in the typical Western diet that includes high amounts of omega-6 fats.7 EPA and DHA can be synthesized from ALA, but EPA and DHA synthesis may be insufficient under certain conditions.

While the polyunsaturated fats known as omega-6 fatty acids are essential to optimal health, most Americans and citizens of other Western nations consume far too many omega-6 polyunsaturated fatty acids and not enough omega-3 polyunsaturated fatty acids. In fact, some Western diets consists of 20 parts of omega-6 to only one part of omega-3. For optimum health, the ratio of omega-6 to omega-3 fatty acids should be between 1:1 and 4:1. This severe imbalance that occurs with most people contributes to the development of long-term health problems.

Studies associate the Mediterranean diet, rich in omega-3 fatty acids, olive oil, and antioxidant-rich fruits, vegetables, and herbs, with lowered cardiovascular risk and increased life span.9-15 Other studies support omega-3’s importance in cardiovascular health.16,17 In fact, the FDA states that supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

The typical American diet is loaded with foods that contain arachidonic acid (like egg yolk, red meat, poultry, and dairy products) or stimulate the production of excess arachidonic acid in the body (foods rich in highglycemic carbohydrates, saturated fats, and omega-6 fatty acids).

Scientific studies show that excess arachidonic acid increases levels of the 5-lipoxygenase (5-LOX) enzyme, which can induce undesirable effects in cells.* This culminates in the excess accumulation of leukotriene B4, a pro-inflammatory compound that attacks the joints, the arterial wall, and other tissues.*

In India, extracts from the Boswellia plant have been used for centuries as fluid balancing agents.71 Recent human studies have confirmed that a specific Boswellia extract known as AKBA (3-O-acetyl-11-keto-ß-boswellic acid) selectively inhibits 5-LOX.72 Unlike other boswellic acids that only partially inhibit 5-LOX,72,73 AKBA binds directly to 5-LOX, effectively suppressing its pro-inflam-matory activity.

5-LOXIN is a registered trademark of P.L. Thomas & Co., Inc. U.S. patents pending.