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Life Extension Update

September 02, 2004 Printer Friendly
In this issue

Life Extension Update Exclusive:

Study finds DHA important for Alzheimer’s patients

Protocol:

Alzheimer’s disease

Featured Products:

Mega EPA/DHA

PC-Ginkgo capsules

Life Extension Magazine:

September 2004 Life Extension magazine now online!

Life Extension Update Exclusive

Study finds DHA important for Alzheimer’s patients
In the September 2 2004 issue of the journal Neuron, (http://www.neuron.org/) UCLA Professor of Neurology Greg Cole, PhD, and colleagues have shown how docosahexaenoic acid (DHA), an omega-3 fatty acid found in fish oils, protects against some of the damage caused by Alzheimer’s disease (AD), in a mouse model. Epidemiologic studies have indicated an inverse association between increased intake of omega-3 fatty acids and Alzheimer’s disease risk, but whether this is a cause or an effect of the disease has been a matter of speculation.

For the current study, the UCLA team used mice bred to have the human version of a mutant amyloid precursor protein which produces the brain plaques characteristic of Alzheimer’s disease. Older animals who were already showing evidence of the Alzheimer’s lesions were fed omega-3 fatty acid depleted diets while another group of the same age was given the diet supplemented with DHA derived from algae. Two additional groups of mice who did not have the Alzheimer’s gene were provided with regimens identical to those of the treatment groups.

When the animals were examined after five months, the researchers found significant damage to the synapses of the nerve cells in the brains of the mice with Alzheimer’s disease who were on DHA deficient diet. (Synapses are the connections between nerve cells through which the cells communicate.) The changes were similar to those observed in the brains of human Alzheimer's disease patients. Supplementation with DHA helped prevent this damage, as well as providing protection against oxidative stress in the mice who received it.

In studies in which behavior was examined, the mutant mice who received low-DHA diets showed deficits in memory and learning that did not occur in mice supplemented with DHA.

The authors explained their findings by noting that oxidative stress is the probable cause of the loss of DHA, which can be controlled by increased intake of the fatty acid and should be reduced by dietary or supplementary antioxidants.

Dr Cole commented, "This is the first proof that our diets affect how our brain cells communicate with each other under the duress of Alzheimer's disease. We saw that a diet rich in DHA, or docosahexaenoic acid, dramatically reduces the impact of the Alzheimer's gene. Consuming more DHA is something the average person can easily control. Anyone can buy DHA in its purified form, fish-oil capsules, high-fat fish or DHA-supplemented eggs."

Dr Cole and colleagues conclude that the results of their research, “support the idea that increased DHA intake should be considered as a potential neuroprotective strategy for AD." (Calon F, L GP, Yang F et al, “Docosahexaenoic acid protects from dendritic pathology in an Alzheimer’s disease mouse model,” Neuron, vol 43, 633-645.)

Protocol

Alzheimer’s disease
The most characteristic features of Alzheimer's disease are senile plaques of beta-amyloid peptide, neurofibrillary tangles involving tau protein, loss of synapses, and (ultimately) the death of neurons. Although neurofibrillary tangles are more closely associated with neuronal death than beta-amyloid, the evidence is becoming convincing that beta-amyloid is the factor most responsible for starting the degenerative processes of Alzheimer's disease.

Free-radical damage (oxidative stress) is a significant cause of biological aging. It is well-known that neurons are extremely sensitive to attacks by destructive free radicals. The following evidence supports the hypothesis of free-radical damage being a central cause in Alzheimer's disease (Christen 2000):

  • The brain lesions present in the brains of Alzheimer's disease patients are typically associated with attacks by free radicals (for example, damage to DNA, protein oxidation, lipid peroxidation, and advanced glycosylation end products).
  • Metals (such as iron, copper, zinc, and aluminum) are often present. These metals have a catalytic activity which produces free radicals.
  • Beta-amyloid is aggregated and produces more free radicals in the presence of free radicals.
  • Beta-amyloid toxicity is eliminated by free radical scavengers.
  • Apolipoprotein E (ApoE) is subject to attacks by free radicals, and apolipoprotein E peroxidation has been correlated with Alzheimer's disease. In contrast, apolipoprotein E can act as a free radical scavenger.
  • Alzheimer's disease has been linked to mitochondrial anomalies affecting cytochrome c oxidase. These anomalies may contribute to the abnormal production of free radicals.
  • Free radical scavengers (such as vitamin E, selegeline, and ginkgo biloba extract) have produced promising results in Alzheimer's disease.

http://www.lef.org/protocols/prtcl-006.shtml

Featured Products

Mega EPA/DHA capsules

Omega-3 fatty acids that are found in cold water fish (and fish oil) and perilla and flaxseed oils, have the ability to suppress the production of inflammatory mediators. Omega-3 oils contain the essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can be lacking in the typical Western diet that includes a high amount of omega-6 fats.

http://www.lef.org/newshop/items/item00625.html

PC-Ginkgo capsules

Phosphatidylcholine (PC), a major structural component of brain cells, is important for intelligence and memory. Ginkgo functions via many mechanisms to maintain healthy neurological function. This supplement combines these two widely documented brain-boosting nutrients into one capsule. Also included, are medium chain triglycerides (MCT) —saturated fatty acids that do not induce cholesterol formation, are burned as fuel, and have shown significant health benefits.

Life Extension Magazine

September 2004 Life Extension magazine now online!

Reports

Cover story: Novel fiber limits sugar absorption

 

Magnesium in hypertension prevention and control, by Jay S Cohen, MD

 

Thyroid deficiency: Preventing a metabolic meltdown, by Raphael Kellman, MD

 

An innovative new treatment for migraine, by Dr Sergey A Dzugan

Departments

 

As we see it

 

In the news: Omega-3 fatty acids stabilize atherosclerotic plaques; Anti-prostate cancer vaccine shows promise; Short-term statin use depletes coQ10 levels; Sex hormones implicated in prostate enlargement; Antioxidants may protect against hearing loss; Fossils record dramatic gain in human longevity; Scientists identify gene thought to control aging

 

Profile: Scott Radow by Dave Tuttle

 

Case History: Hormone therapy and supplements bolster weight loss efforts, by By William Davis, MD, FACC

 

Ask the doctor: Nutrients for treating obsessive-compulsive disorder, by Eric V Braverman, MD

 

All about supplements: I3C may reverse autoimmunity and extend lifespan, by Terri Mitchell

 

September 2004 abstracts

Questions? Comments? Send them to ddye@lifeextension.com or call 954 766 8433 extension 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
LifeExtension.com
1100 West Commercial Boulevard
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954 766 8433 extension 7716

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