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| Life Extension Update
Exclusive More benefits for resveratrol
A study published online in the American Journal of Physiology--Heart
and Circulatory Physiology (http://ajpheart.physiology.org/)
in October of this year has found yet another benefit for resveratrol,
a compound found in red grapes and red wine. The current research shows
that the compound may limit the effects of cardiac fibrosis, a hardening
of the heart tissue that can occur with high blood pressure and heart
failure, which results from the overactivation of heart cells known as
cardiac fibroblasts. The condition leads to a failure of the heart to
pump blood efficiently. The study represents the first time that resveratrol's
direct effect on cardiac fibroblasts has been examined.
J. Gary Meszaros and colleagues at Northeastern Ohio Universities College
of Medicine pretreated rat heart fibroblast cells with resveratrol and
found that the actions of the hormone angiotensin II were prevented. Angiotensin
II is produced in high amounts in heart failure and hypertension in an
effort to help repair damage to the heart, but can cause damage by stimulating
the manufacture of excessive cardiac fibroblasts which leads to the overproduction
of collagen. Assistant professor of human nutrition at Ohio State University
and study coauthor Joshua Bomser explained, "This hypersecretion
of collagen leads to a stiffening of the heart muscle. So the heart has
to work harder to pump blood, which causes further damage to the myocardium."
In addition to preventing angiotensin II from stimulating the overgrowth
of fibroblasts, resveratrol prevented the cells from becoming myofibroblasts,
which secrete large quantities of collagen. This differentiation is another
important step in the development of cardiac fibrosis.
"These results suggest that resveratrol has antifibrotic properties
in the myocardium," Dr Bomser concluded.
The research was supported in part by the American Heart Association-Ohio
Valley Affiliate. |
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| Protocol
Hypertension
There are numerous processes that have been identified as contributing
causes to hypertension or to the diseases that are related to hypertensive
vascular disease. Because of the complex relationships associating the
symptom of hypertension with the cardiovascular diseases, diseases such
as hypertensive vascular disease, congestive heart failure, renal disease,
stroke, arteriosclerosis, atherosclerosis, and diabetes are often interrelated.
They all can ultimately express the symptom of high blood pressure or
develop as a result of high blood pressure. Each disease can both cause
hypertension, and in turn, is aggravated by hypertension. Control of hypertension
can sometimes prevent the development of some diseases like congestive
heart failure, but only modestly slow the progression of diseases like
diabetes and atherosclerosis. In the end, uncontrolled hypertension generally
leads to death secondary to atherosclerosis (Williams 2001). Most deaths
due to hypertension result from myocardial infarction or congestive heart
failure.
We believe that damaged vascular endothelial cells contribute to and
perpetuate hypertensive vascular disease, which then progresses to many
of the more serious, well-recognized cardiovascular disorders. We believe
the most immediate key is control of the diet (especially salt intake)
and control of the kinds of fat consumed. We cannot overemphasize the
importance of avoiding trans-fatty acids, saturated fats, and sugar in
favor of omega-3 essential fatty acids, particularly DHA. It is important
to get the right combination of GLA, DHA, EPA, monounsaturated fats, fat-soluble
antioxidant nutrients (such as coenzyme Q10 and vitamin E), natural vasodilators
(arginine), and a good diet based on fruits and vegetables. Such a diet
or supplementary dietary protocol will likely reduce the incidence of
hypertension and stop the disease progression at it source.
http://www.lef.org/protocols/prtcl-060.shtml
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Featured
Products
Resveratrol
capsules
Red wine contains resveratrol, but the quantity varies depending on where
the grapes are grown, the time of harvest, and other factors. After more
than two years of research, a standardized resveratrol extract is now
available as a dietary supplement. This whole grape extract contains a
spectrum of polyphenols that are naturally contained in red wine such
as proanthocyandins, anthocyanins, flavonoids, etc.
http://www.lef.org/newshop/items/item00655.html
Indole-3-carbinol/Resveratrol
capsules
Resveratrol, an extract that comes from grapes, vines and other plants,
has been found by researchers to possess certain properties that may be
important in maintaining optimal health.
Having isolated this nutrient from organic red grapes, a standardized
extract has been developed and combined with I3C to create one of the
most useful nutrients in safeguarding one's health.
http://www.lef.org/newshop/items/item00654.html |
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Don’t
miss out on your chance to order holiday gifts of health during Super
Sale!
Super Sale is the perfect time to order holiday gifts of health for your
family and friends. Products ordered during Super Sale are discounted
by 10 percent until January 31, 2005 (members of Life Extension continue
to receive their 25 % discount in addition to the 10 % discount).
To ensure that your gifts arrive on time:
- For products shipped via UPS Ground, order before December 16.
- For products shipped UPS third day air, order before December 21.
- For products shipped UPS second day air, order before December 22.
- For products shipped UPS overnight, order before December 23.
Order now and avoid the last minute rush by calling 1-800-544-4440, or
order online.
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If you have questions or comments concerning this issue or past issues
of Life Extension Update, send them to ddye@lifeextension.com
or call 954 766 8433 extension 7716.
For longer life,
Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
LifeExtension.com
1100 West Commercial Boulevard
Fort Lauderdale FL 33309
954 766 8433 extension 7716
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