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| Life Extension
Update Exclusive High blood vitamin D levels reduce
risk of prostate cancer
The 2005 Multidisciplinary Prostate Cancer Symposium held in Orlando,
Florida this month was the site of a presentation by Haojie Li MD,
PhD of Harvard University School of Public Health of the finding
that high plasma vitamin D levels could help protect against the
development of prostate cancer and may also prevent the more aggressive
form of the disease.
Using blood samples obtained in 1982 from 2400 healthy participants
in the Physician’s Health Study, Dr Li and colleagues measured
25-hydroxyvitamin D (25 D) and 1,25 dihydroxyvitamin D (1,25 D),
and ascertained variations in the vitamin D receptor gene. Samples
from 1,029 men who developed prostate cancer over the 13 to 18 year
follow-up period were age and smoking-status matched with blood
from 1,371 healthy men.
The Harvard and Brigham and Women’s Hospital researchers
found that men whose plasma levels of both forms of the vitamin
were higher than the median of the current study population experienced
a 45 percent lower risk of developing aggressive prostate cancer
than those with lower levels. Presence of a genotype called homozygous
Fokl FF combined with high vitamin D levels lowered overall risk
by 55 percent, and the risk of developing aggressive disease by
77 percent.
Dr Li, who was the study’s lead investigator, concluded,
"Our findings suggest that vitamin D plays an important protective
role against prostate cancer, especially clinically aggressive disease.
This research underscores the importance of obtaining adequate vitamin
D through skin exposure to sunlight or through diet, including food
and supplements." |
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| Protocol
Prostate
Cancer
Besides laboratory testing, physical examination, and investigative
procedures to rule out the presence of prostate cancer (PC) and
other diseases, an action plan to prevent their development should
be considered. These types of preventive measures are preemptive,
or defensive, measures. The most apparent of these relates to what
we eat and drink.
Measures to prevent PC must be a routine part of the counsel that
general practitioners and internists give their patients. Selenium
intake of at least 200 mcg a day should be a consideration in the
prevention of PC. Low plasma selenium is associated with a four-
to fivefold increased risk of PC. In addition, levels of plasma
selenium also decrease with age, resulting in middle-aged to older
men being at a higher risk for low selenium levels.
A large-scale study of almost 11,000 men in Maryland showed that
the protective effects of high selenium levels, and similarly that
of the alpha-tocopherol isomer of vitamin E, were only observed
when the concentrations of the gamma tocopherol isomer of vitamin
E were also high. In this study, the risk of PC declined with increasing
concentrations of alpha-tocopherol, with the highest concentration
associated with a 68% PC risk reduction. For gamma-tocopherol, men
with levels in the highest fifth of the distribution had a fivefold
greater reduction in the risk of developing PC than men in the lowest
fifth . The observed interaction between alpha-tocopherol, gamma-tocopherol,
and selenium suggested that combined alpha- and gamma-tocopherol
supplements, used in conjunction with selenium, should be considered
in future PC prevention trials.
http://www.lef.org/protocols/prtcl-138.shtml
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Featured
Products
Vitamin D3 capsules
Vitamin D is necessary for utilization of calcium and phosphorus
and in many ways acts as a hormone. The two most important forms
of vitamin D are cholecalciferol (D3), which is derived from our
own cholesterol and ergocalciferol (D2), a plant analogue derived
from the diet. The cholecalciferol supplied by the Life Extension
Foundation is synthetic, but its form is identical to that which
is derived from cholesterol and synthesized by sunlight on the skin.
Cholecalciferol is essential for bone growth and maintenance of
bone density.
http://www.lef.org/newshop/items/item00251.html
Gamma
E Tocopherol with Sesame Lignans
The primary purpose of supplementing with vitamin E is to suppress
damaging free radicals. Scientific studies have identified the gamma-tocopherol
form of vitamin E as being critical to human health.
New research shows that sesame lignans increase gamma-tocopherol
levels in the body while reducing free radical damage. In response
to these findings, Life Extension has reformulated the popular Gamma
E Tocopherol supplement to replace tocotrienols with sesame lignans.
http://www.lef.org/newshop/items/item00759.html |
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Dr
Eric R. Braverman returns to Life Extension March 29 to April 7
Eric R. Braverman, MD, one of the foremost integrative medical
experts, will be visiting South Florida and conducting individual
screening and diagnostic procedures at the Life Extension Medical
Center, located at 1100 West Commercial Boulevard in Fort Lauderdale.
Eric R. Braverman, MD is available by appointment only on March
29-April 7, 2005, at the Life Extension Medical Center, for in-depth
nutritional consultations, physical exams, ultrasound testing, memory
testing, cardiopulmonary testing, and disease reversal, including
assessments and treatment of such conditions as ADHD, hypertension,
diabetes, memory loss, and osteoporosis.
To schedule an appointment with Dr. Braverman at Life Extension,
call PATH Medical toll-free at 1-888-231-7284, or email your contact
information to pathmedical@aol.com.
http://www.lef.org/braverman_1204.htm
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Questions? Comments? Send them to ddye@lifeextension.com
or call 954 766 8433 extension 7716.
For longer life,
Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
LifeExtension.com
1100 West Commercial Boulevard
Fort Lauderdale FL 33309
954 766 8433 extension 7716
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