Life Extension Final Clerance Sale

Life Extension Update

September 6, 2005 Printer Friendly
In this issue
 

Life Extension Update Exclusive

   

Vitamin D drug plus NSAID suppresses prostate cancer cell growth

 

Protocol

   

Prostate cancer adjuvant therapy

 

Featured Products

   

Enhanced Natural Prostate with Cernitin® and beta-Sitosterol

   

Vitamin D3 Capsules

 

Life Extension

   

Join the Life Extension Foundation

Life Extension Update Exclusive

Vitamin D drug plus NSAID suppresses prostate cancer cell growth

The findings of Stanford University School of Medicine researchers published in the September 1 2005 issue of the journal Cancer Research (http://cancerres.aacrjournals.org) show that adding a nonsteroidal anti-inflammatory drug (NSAID) to the active form of vitamin D known as calcitriol reduces the growth of cultured prostate cancer cells by up to 70 percent. The study’s lead author, professor of medicine David Feldman, MD had previously demonstrated that calcitriol limits prostate cancer cell growth.

Dr Feldman’s team tested calcitriol and the NSAIDs naproxen and ibuprofen on prostate cancer cell cultures and found a 25 percent growth reduction associated with each drug. But when both calcitriol and a NSAID were administered in amounts equal to one-tenth to one-half of the quantities used when either drug was tested alone, a 75 percent reduction occurred.

DNA microarray tests revealed two genes affected by calcitriol that are involved in the production and breakdown of prostaglandins. Prostaglandins are hormones that can activate the inflammatory response, which is associated with cancer growth. Nonsteroidal anti-inflammatory drugs work similarly by blocking an enzyme, COX-2, necessary for prostaglandin synthesis.

Dr Feldman commented, "There is great enhancement when the drugs are given together, using what we think is a safe dose in humans."

"NSAIDs have their own risks," Dr Feldman cautioned. "So, we have to be careful even with lower doses and we still need to watch the patients very closely if we intend to keep them on these drugs for extended periods of time. But we are aiming to find doses that are less toxic and far more tolerable for the patient."

Dr Feldman has initiated a clinical trial that is testing the effects of administering naproxen twice daily to prostate cancer patients along with a once per week dose of calcitriol. Once per week dosing avoids the problem of too much calcium in the blood that is associated with taking calcitriol on a daily basis.

The authors “propose that a combination of calcitriol and nonselective NSAIDs might be a useful chemopreventive and/or therapeutic strategy in men with prostate cancer, as it would allow the use of lower concentrations of both drugs, thereby reducing their toxic side effects.”

Protocol

Prostate cancer adjuvant therapy, by Stephen B, Strum, MD and Jonathan E. McDermod, PharmD

Adjunctive therapies known to have an effect on PC include the use of vitamin D. Published studies using more potent synthetic vitamin D analogs such as Rocaltrol or calcitriol have shown a slowing effect on PC growth (Gross et al., J. Urol., 1998). These analogs affect the p27Kip1 oncogene that results in over-expression of enzymes that inhibit part of the tumor cell cycle (Koike et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 1997). In short, synthetic vitamin D analogs cause a G1 arrest in the cell cycle by over-expression of cyclin-dependent kinase inhibitors (CDKIs). We routinely use 0.5 mcg of Rocaltrol at bedtime. Rocaltrol requires a physician's prescription. When we employ Rocaltrol, we do so in a comprehensive setting of improving bone integrity. As mentioned earlier, the use of ADT results in an increase in bone resorption due to activation of bone-resorbing cells called osteoclasts. Excessive bone resorption leads to release of bone-derived growth factors that have been shown to play an important role in increasing PC growth. We block this bone resorption by using drugs in the bisphosphonate family. Examples of such drugs currently in use include alendronate (Fosamax), pamidronate (Aredia), and most recently Risedronate (Actonel).

In conjunction with dietary restriction of calories and alteration in the nature of the calories consumed as well as moderating our exercise, there is evidence that aging, degenerative disease, and cancer are all expressions of varying degrees of cellular oxidative damage. In fact, fat itself induces the generation of fatty acid peroxides that generate damaging free radicals. The concept here is that living organisms are subject to oxidation just as metal is subject to rusting. As part of aging, we see the sequelae of such oxidation manifested in the graying of hair, short-term memory loss, cataract formation, gum and jaw recession, vascular disease, cardiac disease, degenerative joint disease, and sun-induced skin changes ranging from wrinkling to skin cancer. The majority of items in health food stores today are antioxidants.

In regards to PC, there are now studies that show that vitamin E and selenium use will decrease the incidence as well as the mortality from PC. The ATBC study by Heinonen et al. (J. Natl. Cancer Inst., 1998) demonstrated a 32% decrease in the incidence of PC and a 41% lower mortality rate from PC in men taking alpha-tocopherol (vitamin E).

http://www.lef.org/protocols/prtcl-134.shtml

Featured Products

Natural Prostate with Cernitin® & beta-Sitosterol

Enhanced Natural Prostate Formula contains the most scientifically substantiated plant extracts to alleviate prostate discomfort, plus lycopene and boron to help protect the prostate and maintain its healthy function.

This formula contains a standardized flower pollen extract called Cernitin(R), which studies indicate helps to maintain healthy prostate function, even when taken by itself. The newest ingredient, beta-sitosterol, is the most active constituent of pygeum and interferes with the formation of prostaglandins that cause swelling in the prostate.

http://www.lef.org/newshop/items/item00875.html

Vitamin D3 capsules

Vitamin D is necessary for utilization of calcium and phosphorus and in many ways acts as a hormone. The two most important forms of vitamin D are cholecalciferol (D3), which is derived from our own cholesterol and ergocalciferol (D2), a plant analogue derived from the diet. The cholecalciferol supplied by the Life Extension Buyers Club is synthetic, but its form is identical to that which is derived from cholesterol and synthesized by sunlight on the skin. Cholecalciferol Vitamin D is essential for bone growth and maintenance of bone density.

http://www.lef.org/newshop/items/item00251.html

Join the Life Extension Foundation

Too many people are dying today as a result of medical ignorance and apathy. The Life Extension Foundation is breaking down the bureaucratic barriers that deny human beings access to validated life-saving therapies. If you join the Life Extension Foundation today, you’ll receive:

The 1,665-page reference book called Disease Prevention and Treatment. This hardcover fourth edition reveals what doctors are NOT doing to save the lives of their patients and contains novel approaches to prevent and treat 134 medical disorders. The cover price is $49.95, but is sent free to new Life Extension members.

Life Extension magazine … an over 100-page monthly publication filled with medical research findings, inside scientific reports, and practical guidance about using nutrients and hormones to slow aging. Life Extension magazine provides a continuous stream of knowledge about the practical application of new discoveries that enables readers to protect their precious health.

Discounts on prescription medications, blood tests, and dietary supplements that greatly exceed the membership dues.

And more!

http://www.lef.org/featured-articles/benefits.html

Questions? Comments? Send them to ddye@lifeextension.com or call 954 202 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
954 766 8433 extension 7716

Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp

Help spread the good news about living longer and healthier. Forward this email to a friend!

View previous issues of Life Extension Update in the Newsletter Archive.