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Life Extension Update

June 3, 2006 Printer Friendly
In this issue

Life Extension Update Exclusive


Encouraging news for couch potatoes


Health Concern


Calorie restriction


Featured Products


Super Absorbable CoQ10™ with d-Limonene


Grapeseed Extract with Resveratrol


Life Extension magazine


Life Extension magazine June 2006 now online


Life Extension


Blood test sale extended through Monday, June 5 2006!

Life Extension Update Exclusive

Encouraging news for couch potatoes

The results of a study published online on May 23, 2006 in the Journal of Clinical Endocrinology and Metabolism revealed that calorie restriction (CR) is more effective than exercise at influencing factors associated with extended lifespan. Unfortunately for non-exercisers, the finding doesn’t negate exercises’ other health and disease prevention benefits.

For the current study, researchers at Washington University School of Medicine in St. Louis led by assistant professor of medicine Luigi Fontana, MD, PhD, compared 28 members of the Calorie Restriction Society, whose daily calorie intake averaged about 1,800 for the past six years, with 28 sedentary individuals and 28 endurance runners who consumed a standard Western diet consisting of approximately 2,700 calories per day. Body fat and trunk fat were similar among the calorie restricted and exercise groups, and lower than that of the non-restricted non-exercising group.

The research team found that the calorie restricted diet was associated with lower levels of the thyroid hormone T3 (which controls energy balance and cellular metabolism) compared to the other two groups, while T4 (the other thyroid hormone) as well as thyroid stimulating hormone remained normal, showing that the calorie restricted participants did not have clinical hypothyroidism. In addition, the restricted group had lower levels of an inflammatory molecule known as tumor necrosis factor alpha than the nonrestricted groups. When T3 levels of the exercising group on the Western diet were examined, they were found to be similar to those of the non-exercising Western diet group. The combination of reduced T3 and tumor necrosis factor alpha may retard the aging process by lowering the body’s metabolic rate and reducing oxidative damage to the tissues.

"The difference in T3 levels between the CR group and the exercise group is exciting because it suggests that CR has some specific antiaging effects that are due to lower energy intake, rather than to leanness,” stated Dr Fontana. “These findings suggest that although exercise helps prevent problems that can cut life short -- such as obesity, diabetes and cardiovascular disease -- only CR appears also to have an impact on primary aging."

Study coauthor and Washington University School of Medicine professor of medicine John O. Holloszy, MD, found similar results in a study conducted with rats in 1997. "Sedentary rats who ate a standard diet had the shortest average life-spans," Dr Holloszy stated. "Those who exercised by running on a wheel lived longer, but animals on calorie restriction lived even longer."

Drs Fontana and Holloszy will be conducting a new investigation called the Comprehensive Assessment of the Long Term effects of Reducing Intake of Energy (CALERIE) study, which will find out whether calorie restriction will lower serum T3 and inflammation as well as improve heart function and other markers of aging among normal weight adults as it has among members of the Calorie Restriction Society. "We want to learn whether calorie restriction can reverse some of these markers of aging in healthy people," Dr Holloszy explained. "It's going to be many years before we know whether calorie restriction really lengthens life, but if we can demonstrate that it changes these markers of aging, such as oxidative damage and inflammation, we'll have a pretty good idea that it's influencing aging in the same way that CR slows aging in experimental animals."

Health Concern

Calorie restriction

It appears that caloric restriction works by slowing biological aging in many ways, including decreasing ROS damage to cells, limiting inflammation, enhancing insulin sensitivity, and repairing damaged cells. Certain nutrients have demonstrated similar effects, leading one group of researchers (Lemon JA et al 2005) to attempt to mimic CRON with a formula containing 31 ingredients that included a wide range of antioxidants and nutrients that have been extensively studied in humans (such as vitamin E, vitamin C, coenzyme Q10, glutathione precursors, and essential fatty acids).

This formula was given to normal mice and mice that over-expressed growth hormone. The mice that over-expressed growth hormone were larger and had a shorter life span than the normal ones, presumably because they aged faster.

The results were dramatic. Supplementation extended the life span of the growth hormone mice by 28 percent, to 431 days. In normal mice, supplementation extended life span by 11 percent on average, from 688 days to 765 days (Lemon JA et al 2005).

How does this 11 percent increase in longevity in normal mice compare to caloric restriction? Although a CRON group was not included in the study described above, other investigators have reported that 40 percent restriction in calories increased survival in the same strain of mice about 19 percent (Forster MJ et al 2003). Thus, supplementation yielded about half as much longevity as caloric restriction.


Featured Products

Super Absorbable CoQ10™ with d-Limonene

Coenzyme Q10 is incorporated into the mitochondria of cells throughout the body where it facilitates and regulates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10’s ability to restore mitochondrial function has a profound effect on one’s overall health.

As people age, their natural synthesis of CoQ10 slowly declines. When people take “statin” cholesterol lowering drugs, CoQ10 synthesis can be reduced even further.


Grapeseed Extract with Resveratrol

Life Extension's Grapeseed Extract with Resveratrol formula provides a concentrated blend of standardized proanthocyanidins found in grape seed and skins. The proanthocyanidins and flavonoids in this new formula are rapidly absorbed and distributed throughout the body, helping to eliminate free radicals while promoting healthy collagen formation.


Life Extension magazine June 2006 now online



On the cover: Media Bias, Conflicts of Interest Distort Study Findings on Supplements, by Lyle MacWilliam, MSc, FP


Mainstream doctors still confused about homocysteine, by William Faloon


The sunscreen paradox: Popular misconceptions about skin cancer prevention, by Steven V. Joyal, MD


Superoxide dismutase: Boosting the body's primary antioxidant defense, by Dale Kiefer


Ashwagandha: Stress reduction, neural protection, and a lot more from an ancient herb, by Dale Kiefer



In the news: Supplements help elderly avert disease; Chromium, B vitamins prevent weight gain; Tea polyphenols may reduce ovarian cancer risk; Resveratrol offers neuroprotective benefits; Olive polyphenols protect blood vessels; Elevated HDL protects against coronary events; Soy, stevia, counter metabolic syndrome


Wellness profile
Kaicho Nakamura: Strength and tranquility, by Philip Smith


As we see it: Dietary supplements attacked by the media, by William Faloon


June, 2006 journal abstracts: Homocysteine, sun protection, superoxide dismutase (SOD), ashwagandha


Blood test sale extended through Monday, June 5 2006!

Due to the overwhelming popularity of this year's Blood Test Super Sale, we're extending the sale by five more days! This means you have until Monday, June 5 to enjoy deeply discounted prices on comprehensive blood test services.

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If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954 202 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
954 766 8433 extension 7716

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