Life Extension Update Exclusive
American Heart Association journal concludes majority of coronary events in older men may be preventable
A report published online in the journal Circulation on July 3, 2006 concluded that coronary events in older American men could be prevented in large part by adopting just five healthy lifestyle habits. The study is the first to examine the role of a healthy lifestyle in heart disease prevention among middle aged and older men.
Associate professor of epidemiology and nutrition Eric B. Rimm and research fellow Stephanie Chiuve of Harvard School of Public Health, and their colleagues conducted a 16 year follow-up of 42,847 participants in the Health Professionals Follow-Up Study, which enrolled 51,529 male health professionals aged 40 to 75 in 1986. Questionnaires administered every two years provided updated information on medical conditions such as hypertension and elevated cholesterol, medication use, and lifestyle factors. Healthy lifestyle factors were defined as not smoking, daily moderate to vigorous exercise, consuming alcohol in moderation, maintaining a healthy weight, and consuming a healthy diet as based on the Harvard School of Public Health Alternate Healthy Eating Index.
Over the follow-up period there were 2,183 cases of nonfatal heart attack and fatal coronary heart disease. Participants whose questionnaire responses concerning all five healthy lifestyle practices placed them in the low risk category had an 87 percent reduced risk of coronary heart disease compared to men who adhered to none of the five factors. Adopting at least two factors lowered risk by 27 percent.
The researchers estimated that 62 percent of the coronary events that occurred could have been prevented by adherence to the five lifestyle practices. Even men being treated for hypertension or cholesterol with drugs for these conditions could have had 57 percent of coronary events prevented by these improvements.
“A healthy lifestyle can be an effective, nonpharmacological approach to reducing coronary heart disease among men,” the authors conclude. Dr Cuive commented, "It's never too late to make changes to become healthier.”
Coronary artery disease and atherosclerosis
In the world of conventional medicine, atherosclerosis is a widely misunderstood disease, perhaps because of a fundamental misconception about the nature of the arteries themselves. In this antiquated view, the arteries have been thought of as stiff pipes that gradually become clogged with excess cholesterol floating around the bloodstream. The solution recommended most often has been to reduce the dietary consumption of fats in order to lower levels of cholesterol, triglycerides, and low-density lipoprotein (LDL) in the blood. Conventional medicine’s preferred method of reestablishing blood flow in clogged arteries is through surgery (coronary artery bypass graft surgery) or by insertion of catheters bearing tiny balloons that crush the plaque deposits against the arterial walls (angioplasty), followed by the implantation of tiny mesh tubes (stents) to keep the arteries open.
Today, our understanding of atherosclerosis has literally redefined the disease. We now understand atherosclerosis as a chronic inflammatory disease that affects the way arteries function at the most basic level. Instead of viewing the arteries as pipes through which blood flows, we now understand that arteries are muscular organs that change and adapt to their environment and contract and expand in response to multiple factors, helping to raise and lower blood pressure and distribute blood throughout the body. Finally, we have begun to unravel the biochemical processes that underlie atherosclerosis.
The following nutrients have been shown to improve endothelial function and reduce the damage caused by oxidized LDL, slowing the progression of atherosclerosis:
- Folic acid—800 to 5000 micrograms (mcg) daily
- Vitamin B12—300 to 2000 mcg daily
- EPA and DHA—1400 milligrams (mg) EPA and 1000 mg DHA daily
- PLC—1000 to 2000 mg daily
- L-arginine—3000 to 12,000 mg daily (in 3 divided doses)
- Lipoic acid—150 to 300 mg daily
- Garlic—1200 mg daily (Kyolic aged garlic extract)
- Ginkgo biloba—120 mg daily
- Green tea extract—725 mg daily (93 percent polyphenols)
- Quercetin—500 to 1000 mg daily (water-soluble quercetin)
- Vitamin C—1000 to 3000 mg daily
- Vitamin E—400 international units (IU) daily (with 200 mg gamma tocopherol)
- Vitamin K—10 mg daily
- Vitamin B6—100 to 750 mg daily
Peak ATP™ with GlycoCarn™
Propionyl-L-Carnitine (PLC) plays an important role in protecting the function and health of endothelial cells. PLC passes across the mitochondrial membrane to supply carnitine directly to the energy-producing organelles of all cells. Carnitine is essential for mitochondrial fatty acid transport and energy production. This is important because endothelial cells burn fatty acids for 70 percent of their energy.
Kyolic Reserve Aged Garlic Extract
When garlic is aged, its harsh and highly odorous compounds are converted into more beneficial and much less odorous compounds. Numerous studies have suggested that supplementing one’s diet with aged garlic extract may be beneficial. Published data about aged garlic extract shows that it:
- Helps maintain healthy endothelial function and structure
- Helps maintain healthy immune function
- Helps maintain healthy cellular DNA structure
Life Extension magazine
Life Extension Magazine July 2006
On the cover: Calorie restriction without hunger! By Steven V. Joyal, MD, and Dale Kiefer
What is nuclear factor-kappa beta? By Julius G. Goepp, MD
DHA and the developing brain, by Julius G. Goepp, MD
Metabolic syndrome: The twenty-first century epidemic, by Steven V. Joyal, MD
Longevity genes and caloric restriction, by Xi Zhao-Wilson, PhD, and Paul C. Watkins, SM, of BioMarker Pharmaceuticals
Aspirin: Remarkable research uncovers lifesaving benefits beyond cardiovascular protection
A4M: Blazing new paths in antiaging medicine, by Sue Kovach
As we see it: Eating ourselves to death, by William Faloon
In the news: Plasma coQ10 levels predict melanoma progression; Sunscreens fail to protect against harmful UVA rays; Vitamins C and E, ibuprofen may prevent Alzheimer’s; Folate, vitamin B12 decrease breast cancer risk; Prehypertension greatly increases cardiovascular risk; Early diagnosis critical for surviving prostate cancer; Vitamin D and calcium reduce diabetes risk.
Ask the doctor: Familial hypercholesterolemia, by Dr Sergey A Dzugan
July 2006 abstracts: Nuclear factor-kappa beta (Nfkb), DHA, metabolic syndrome, aspirin