Life Extension Update Exclusive
CLA treats diabetes in mice
Penn State researcher Jack Vanden Heuvel has found that conjugated linoleic acid (CLA) given to mice successfully treats type 2 diabetes in a manner similar to that of antidiabetic drugs.
CLA is a fatty acid found in dairy products and meat, formed by the bacteria that exist within the cattle from which these products are derived. Earlier research involving CLA has shown that it helps prevent several cancers in mice, as well as reduces cholesterol and inflammation similar to the latest synthetic diabetes pharmaceuticals. "We wondered if CLA was using the same mechanism, in which case it could be used as an antidiabetes drug," Dr Vanden Heuvel stated.
Dr Vanden Heuvel, who is a professor of molecular toxicology at Penn State's College of Agricultural Sciences and codirector of Penn State's Center of Excellence in Nutrigenomics tested CLA on mice that develop adult onset diabetes, and observed an improvement in insulin action and a reduction in circulating glucose. He found that CLA turns on peroxisome proliferator activated receptors which interact with DNA. This results in a greater number of enzymes that process fatty acids, as well as an increase in insulin sensitivity--the same mechanism as that employed by diabetes medications.
"Antidiabetes drugs act the same way. They mimic the natural activators of the receptors by getting into the cell and interacting with the PPARs to regulate glucose and fat metabolism,” Dr Vanden Heuvel explained.
"And compared to the synthetic drugs used to treated this disease, CLA does not cause weight gain and may in fact decrease overall body fat," he added.
Doctor Vanden Heuvel cautioned that adopting a diet that is high in dairy and meat products to obtain CLA will also increase the intake of undesirable dietary fats. He suggests instead the use of dietary supplements containing CLA or products to which CLA has been added.
Recent advances in dietary science have highlighted the crucial role of insulin in weight gain. Produced in the pancreas, insulin is a critical hormone for the control of blood sugar (glucose). Its job is to transport glucose into cells, where the glucose is burned as fuel. While this process is necessary for life, abnormalities in the insulin-glucose system caused by aging, lack of exercise and poor diet can cause major health problems. In aging, cells become more resistant to the effects of insulin. As cells become increasingly insulin resistant, the body compensates by increasing the number of insulin receptors on cells and secreting more insulin in an attempt to drive more blood sugar into muscle and liver cells (Fulop 2003).
Insulin resistance is a dangerous condition. Research suggests that adipose tissue (fat) is a source of pro-inflammatory chemicals that have a role in the development of insulin resistance (Sharma AM et al 2005). Insulin resistance is associated with obesity (in particular, abdominal obesity) (Greenfield JR et al. 2004).
This increase in insulin (called hyperinsulinemia) and decreased insulin sensitivity have a number of harmful effects, including contributing to diseases associated with being overweight (Zeman et al 2005; Garveyet al 1998)
Over time, high insulin and insulin resistance may lead to type 2 diabetes in susceptible individuals, a major risk factor for heart disease.
Many studies support the anticancer, antiobesity, antidiabetic, and antiatherogenic properties of CLA (Lee et al 1994; Park et al 1997, 1999; West et al 1998; Yamasaki et al 2003). Human clinical trials have shown reductions in body fat from CLA supplementation.
- Supplementation with 1.8 g daily of CLA for 12 weeks reduced body fat in healthy, exercising humans of normal body weight (Thom et al 2001).
- Men with abdominal obesity who consumed 4.2 g daily of CLA for 4 weeks decreased their abdominal diameter (Riserus et al 2001).
- Supplementation with 3.4 or 6.8 g of CLA daily for two weeks decreased body fat mass in overweight and obese people, and the trans-10, cis-12 CLA isomer inhibited the activities of the fat-storage enzyme lipoprotein lipase (Pariza et al 2001).
- The cis-9, trans-11 isomer, a specific isomer of CLA, increases metabolic rate and energy production (thermogenesis) (Ryder et al 2001; Brown et al 2003).
Super CLA Blend with Sesame Lignans 1000 mg
Super CLA Blend is a concentrated blend of free fatty acids derived from safflower oil. Super CLA Blend consists of 78-84% conjugated linoleic acid yielding optimal levels of its two active isomers 18:2 c9,t11 and 18:2 t10,c12, and minimizing the inactive isomers, ensuring a consistent isomer profile.
Super CLA Blend with Sesame Lignans 500 mg
In a study presented at the Experimental Biology 2002 meeting, CLA alone was shown to cause a substantial decrease in fat mass, and for those who received CLA plus guarana, both adipocyte (fat cell) size and number were decreased by 50%. As an added benefit, sesame lignans have been shown to further increase the burning of fat by stimulating fatty acid oxidation in the liver. As with any fatty acid, CLA can be oxidized by free radicals once it has been ingested. Sesame lignans help prevent the oxidation of CLA, providing health benefits without negative impact.
Life Extension magazine
August 2006 issue now online!
On the cover: Health freedom under attack! Drugmaker seeks to deny access to bioidentical hormones, by Dave Tuttle
Jack LaLanne: "Godfather of Fitness" still going strong at 91, by Dave Tuttle
Uncontrolled high blood pressure: A little-known failure of conventional medicine, by Heather S. Oliff, PhD
CoQ10’s new benefits: Unexpected findings support the remarkable effects of CoQ10 in fighting melanoma, diabetes, endothelial dysfunction, and more! By Russell Martin
Natural Relief 1222: An all-natural analgesic cream provides effective topical pain relief, by Greg Freeman
As we see it: Inventor of safer automobile destroyed by federal government, by William Faloon
In the news: Magnesium reduces risk of metabolic syndrome; Melatonin may protect against Alzheimer’s; Creatine mitigates effects of sleep deprivation; Ginger, chili peppers slow cancer growth; Blueberries offer protection for heart vessels; Charred meat linked to prostate cancer; Creatine aids muscular dystrophy management; Good fats, vitamin E reduce ALS risk; Most Americans get no preventive health care; CLA promotes fat loss in legs, abdomen; Fish oil, caloric restriction ease inflammation; Mediterranean diet protects vascular system; Omega-3s aid recovery from mining disaster; Obesity increases women’s breast cancer risk; Resveratrol may protect brain against stroke.
All about supplements: Boron, by Dan Harvey
August, 2006 abstracts: Blood pressure, CoQ10, boron