Life Extension Update Exclusive
Nutrient combo helps prevent hearing loss
A report published online in the journal Free Radical Biology and Medicine described the discovery of researchers at the University of Michigan that including a combination of antioxidant vitamins and magnesium in one’s nutritional regimen may help prevent noise-induced hearing loss.
Josef M. Miller MD, who is a professor in the Department of Otolaryngology at the University’s Medical School, along with Colleen G. Le Prell, PhD and Larry F. Hughes treated guinea pigs with one of the following: vitamins A, C and E; magnesium; A, C and E plus magnesium, or a placebo one hour before and five days after a five hour exposure to 120 decibel sound pressure level noise (comparable to a jet engine at take-off). Although neither antioxidants nor magnesium alone appeared to be protective, animals that received both had significantly less hearing loss and sensory cell death than the other groups. The finding may be useful in developing a protective nutritional therapy for men and women whose employment involves significant exposure to noise, such as military occupations.
The protective mechanisms produced by pretreatment with the nutrients are a reduction in free radicals that form in the cochlea of the inner ear during and after noise exposure, and decreased constriction of blood flow to the inner ear. The nutrients may also have minimized damage to the auditory neurons caused by overstimulation. Treatment administered after noise exposure scavenged the free radicals that continue to from. "Free radical formation bursts initially, then peaks again during the days after exposure," Dr Le Prell explained.
"These agents have been used for many years, but not for hearing loss. We know they’re safe, so that opens the door to push ahead with clinical trials with confidence we’re not going to do any harm," Dr Miller stated. "Ultimately, we envision soldiers would have a nutritional bar with meals and it would give them adequate daily protection."
"Other people would likely benefit by consuming a pill or nutritional bar before going to work in noisy environments, or attending noisy events like NASCAR races or rock concerts, or even using an iPod or other music player," Dr Le Prell added. "Based on an earlier study with other antioxidant agents, we think this micronutrient combination will work even post-noise."
"Similar combinations have been very effective in preventing macular degeneration, and many of these agents have been used with Alzheimer’s and Parkinson’s diseases, stroke-like ischemia, and other conditions that involve neural degeneration," she noted. "You’re always hoping as a basic scientist to find a commonality like that, across other disease processes.”
Tinnitus is a subjective disorder characterized as chronic ringing, roaring, buzzing, humming, chirping, or hissing in the ears in the absence of environmental noise (ATA 2002). Symptoms of tinnitus are frequently found in elderly persons and are often associated with hearing loss related to the aging process (presbycusis). Although the cause is usually unknown, tinnitus can be a symptom of almost any ear disorder, including infection (otitis media), a blocked ear canal (ear wax) or eustachian tube, otosclerosis (overgrowth of bone in the middle ear), labyrinthitis, and Meniere's disease. Even blast injury from explosions has been known to cause symptoms of tinnitus. Additionally, adverse side effects from some drugs (e.g., aspirin and antibiotics) cause tinnitus symptoms.
People in large cities are exposed to potentially damaging loud noises on a daily basis. Studies have shown that noise exposure causes magnesium to be excreted from the body (Mocci et al. 2001). It is possible that supplementing with magnesium could reduce noise-induced ear damage and thus reduce the likelihood of new-onset tinnitus. Few studies document that magnesium relieves tinnitus symptoms, but many patients have experienced relief by using magnesium (Attias et al. 1994).
Many Americans do not obtain adequate amounts of magnesium in their diets. Magnesium is so inexpensive that everyone should consider supplementing at least 500 mg of magnesium daily. This product provides one of the highest concentrations of elemental magnesium per capsule available on the market.
Super Booster Softgels with Advanced K2 Complex
Just one softgel of Super Booster provides:
- Gamma-tocopherol - Increasing evidence indicates that it may be dangerous to use to alpha-tocopherol form of vitamin E without also taking gamma-tocopherol. According to the Proceedings of the National Academy of Sciences, alpha-tocopherol displaces critically important gamma-tocopherol in the cells. While alpha-tocopherol inhibits lipid peroxidation, gamma tocopherol is needed to quench dangerous free radicals such as peroxynitrite.
- Sesame lignans - Studies show that when sesame lignans are added to the diet of rats, a measurement of free radical activity is reduced by 82 percent. Sesame lignans augment the antioxidant effects of both alpha and gamma-tocopherol. A human study showed that gamma-tocopherol plus sesame lignans was 25 percent more effective at suppressing measurements of free radical damage than gamma-tocopherol and tocotrienols.
- Vitamin K2 - A new biologically active form of vitamin K2 known as menaquinone-7 has been added to provide improved vitamin K function. Menaquinone-7 is not metabolized quickly by the liver, so only small amounts are needed to make osteocalcin, the protein that directs calcium into the bones instead of being left in the blood to calcify arteries.
- Lycopene - People who ingest cooked tomato, rich in the carotenoid lycopene, enjoy healthier prostate function. Lycopene also helps guard against LDL oxidation.
- Lutein - Consumption of green vegetables such as collard greens and spinach provides the carotenoid lutein, which helps maintain healthy cell division and protects the endothelial lining of the arteries.
- Ginkgo - The most popular flavonoid supplement is Ginkgo biloba. Hundreds of studies substantiate its multifaceted effects in the promotion of healthy circulatory and neurologic functions.
- Chlorophyllin - The pigment chlorophyllin is vividly seen in green vegetables. Scientific studies indicate that chlorophyllin may be the most potent nutrient to protect against environmental DNA damage.
- Selenium - The FDA states that some scientific evidence suggests consumption of selenium may reduce the risk of certain forms of cancer. However, the FDA has determined this evidence is limited and not conclusive. The ability of selenium to boost glutathione is well established, but most people don't know that there are several different forms of selenium that provide diverse biological benefits.
What’s Hot Archive
Folic acid supplementation slows hearing loss
The January 2, 2007 issue of the Annals of Internal Medicine published the finding of researchers at Wageningen University and Wageningen Centre for Food Sciences, and University Hospital Maastricht in the Netherlands that supplementing older men and women with folic acid slowed age-related hearing loss. Previous research has found an association between diminished hearing and reduced levels of the vitamin.