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Life Extension Update

June 8, 2007 Printer Friendly
In this issue

Life Extension Update Exclusive

Risk factor reduction and medical/surgical treatment cut heart disease deaths in half

Health Concern

Coronary artery disease and atherosclerosis

Featured Products

Natural BP Management

Super Bioactive CoQ10

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Life Extension Update Exclusive

Risk factor reduction and medical/surgical treatment cut heart disease deaths in half

A study published in the June 7, 2007 issue of the New England Journal of Medicine provides an explanation for the finding that deaths from heart disease in the U.S. in the year 2000 have declined to half of what they were just twenty years ago. From 1980 to 2000, deaths from coronary heart disease were reduced in men from 542.9 to 266.8 per 100,000 U.S. residents, and from 263.3 to 134.4 among women.

Simon Capewell, MD of the University of Liverpool, England, along with researchers at the Centers for Disease Control and Prevention in Atlanta applied data from the U.S. Census Bureau and the National Vital Statistic System of the National Center for Health Statistics to the IMPACT mortality model which incorporates major risk factors for coronary heart disease in addition to usual heart disease treatments. They found that approximately 47 percent of the decline in deaths was due to treatments for the disease, including 11 percent attributable to secondary preventive therapies after heart attack or revascularization, 10 percent attributable to initial angina or heart attack treatments, 9 percent to heart failure treatments, 5 percent to revascularization for chronic angina, and 12 percent to other treatments.

Risk factor reduction accounted for 44 percent of the decline, which resulted in approximately 149,635 fewer deaths over the two decades. These improved risk factors included cholesterol reduction, systolic blood pressure reduction, smoking cessation, and improved physical activity levels, although these were offset in part by increases in body mass index and diabetes. Earlier studies which examined U.S. populations from 1968 to 1976, and from 1980 to 1990 found similar reductions in major coronary heart disease risk factors associated with a decline in deaths from the disease.

“Our analyses suggest that approximately half the recent decrease in deaths from coronary heart disease in the United States may be attributable to reductions in major risk factors and approximately half to evidence-based medical therapies,” the authors conclude. “Future strategies for preventing and treating coronary heart disease should therefore be comprehensive, maximizing the coverage of effective treatments and actively promoting population-based prevention by reducing risk factors.

Health Concern

Coronary artery disease

The treatment of atherosclerosis depends on the stage of the disease. Severe disease, in which an artery has significant blockage or unstable plaque deposits, may require intensive care. In most cases, however, less severe disease is treated with a combination of lifestyle changes (including dietary changes) and medication. The following dietary and lifestyle changes have been shown to slow, or even reverse, the effects of atherosclerosis:

  • Reduce dietary saturated fats, cholesterol, and trans-fatty acids.
  • Increase intake of fiber to at least 10 g daily.
  • Consume at least five servings of fruits and vegetables daily.
  • Ensure adequate intake of folic acid (400 to 1000 mg daily) to reduce homocysteine levels.
  • For obese people, lower weight and increase physical activity to reduce the risk factors for metabolic syndrome and to help control blood pressure and reduce cardiac workload.
  • For people with hypertension, limit sodium intake and maintain adequate intake of potassium, calcium, and magnesium.
  • Stop smoking. This is essential.

Blood testing is a very important part of any risk-reduction program for coronary heart disease. Healthy adults should have their blood tested at least once a year. People who have heart disease or multiple risk factors should have their blood tested twice a year to monitor their progress. A comprehensive blood test will measure levels of blood lipids, C-reactive protein, homocysteine, fibrinogen, and other blood markers. Regular blood pressure monitoring is also important.


Featured Products

Natural BP Management

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Pomegranate extract is an abundant source of highly concentrated compounds called punicalagins that function as natural antioxidants and also inhibit angiotensin converting enzyme, thus supporting blood vessel dilation and countering vessel constriction. This patented extract not only supports blood pressure management, but also may provide added cardiovascular protection by promoting healthy endothelial function and maintaining healthy low-density lipoprotein (LDL) oxidation.


Super Bioactive CoQ10

While CoQ10 exists in both ubiquinol and ubiquinone forms, the ubiquinol form has been shown to be vastly more bioavailable than conventional ubiquinone CoQ10. In a study measuring absorption in humans supplementing with 150 mg and 300 mg, far lower doses of ubiquinol CoQ10 produced blood plasma levels of CoQ10 that were equivalent to those produced by much higher doses of ubiquinone.  In fact, it would take up to 8 times more ubiquinone than ubiquinol to raise CoQ10 blood levels to the same level.


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If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954 202 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
954 766 8433 extension 7716

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