Life Extension Update Exclusive
Omega-3 fatty acids help prevent retinopathy
A letter published online on June 24, 2007 in the journal Nature Medicine reported the finding of researchers at Children's Hospital Boston, Brigham and Women’s Hospital, Massachusetts General Hospital, the University of Goteborg in Sweden, and the National Institutes of Health, that omega-3 polyunsaturated fatty acids have a protective effect in mice against the development and progression of deterioration of the retina of the eye, known as retinopathy. Retinopathy in mice shares characteristics with retinopathy of prematurity (ROP) in human infants, as well as with diabetic retinopathy and age-related macular degeneration (AMD) in adults.
Lois Smith, MD, PhD, and Kip Connor, PhD, of Children’s Hospital Boston’s Department of Ophthalmology, and associates gave mice diets high in the omega-3 fatty acids EPA and DHA, or in the omega-6 fatty acid arachidonic acid, and examined the animals' retinas. They found that greater dietary omega-3 fatty acid content reduced the area of vessel loss which leads to the regrowth of abnormal vessels that characterizes retinopathy. “It is remarkable that with only a two percent change in dietary omega-3 intake, we observed an approximate 40-50 percent decrease in retinopathy severity,” Dr Connor stated.
The omega-3s create bioactive mediators which protect against abnormal blood vessel growth by suppressing tumor necrosis factor alpha, an inflammatory protein found in microglia associated with retinal blood vessels. “If omega-3 fatty acids, or these anti-inflammatory mediators, are as effective in humans and they are in mice, simple supplementation could be a cost-effective intervention benefiting millions of people,” Dr Smith observed. “The cost of blindness is enormous.”
"The purpose of our study was to discover and describe the scientific basis for any possible protective role of omega-3 fatty acids against retinopathy,” Dr Smith said. “By identifying the fatty acids, lipids and growth factors involved in both the disease and protective processes, we hope to translate this work to influence the outcome in patients. Our study results suggest that increasing omega-3 fatty acid intake in premature infants may significantly decrease the occurrence of ROP. This changing of lipids by dietary means may also translate to AMD and diabetic retinopathy. If clinical trials find that supplementing with omega-3 fatty acids is as effective in protecting humans against retinal disease as demonstrated by the findings of this study, this cost effective intervention could benefit millions of people."
Retinopathy damages the retina by destroying the capillaries (minuscule blood vessels connecting arteries and veins) that provide blood to the retina, the light-sensitive nerve tissue that sends visual images to the brain. With the onset of retinopathy, these vessels weaken or bulge with microaneurysms that may hemorrhage, leaking blood or fluid into surrounding tissue. When new blood vessels grow on the retina (and into the vitreous), they can cause blurred vision and even temporary blindness. The real danger lies in the scar tissue that ultimately forms, detaching the retina from the back of the eye and often causing permanent loss of vision.
- Long-term antioxidant protection of the eyes can be provided by taking 3 tablets 3 times a day, of Life Extension Mix and 1 capsule a day of the Life Extension Booster formula. These two supplements provide the alpha and gamma forms of vitamin E, lutein, minerals for the formation of superoxide dismutase (SOD), such as zinc, manganese, and copper along with potent B complex vitamins. Some people may also want to take additional vitamin B6 (up to an additional 250 mg).
- Carnosine is an antiglycating agent that helps protect against the damaging effects of glycation. As an oral supplement, two 500-mg capsules daily are recommended. As an eyedrop, carnosine may help prevent protein cross-linking in the retina. One to two drops daily of carnosine eyedrops are recommended. Those with any kind of eye problem may want to apply 1-2 drops several times a day.
- Zeaxanthin and lutein may help filter harmful UVB light and quench free radicals that harm the retina. Suggested dose from diet or supplements is 5 mg a day of zeaxanthin and 15-20 mg a day of lutein.
- Silibinin may help slow the extent of diabetic retinopathy; 250-500 mg a day is suggested.
- Green tea extract is a powerful antioxidant that has shown promise in the treatment of degenerative eye disease; 600-700 mg of a 95% polyphenol extract is suggested.
Taking 2000 mg a day of acetyl-L-carnitine should be considered by those who have retinopathy, particularly if on a vegetarian diet.
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Aging causes irreversible damage to the body’s proteins. The underlying mechanism behind this damage is glycation. A simple definition of glycation is the cross-linking of proteins and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an underlying cause of age-related catastrophes including the neurologic, vascular, and eye problems. Carnosine is a unique dipeptide that interferes with the glycation process.
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