Life Extension Update Exclusive
Red wine, resveratrol protect against food-borne illness
Research presented recently at the Institute of Food Technologists’ annual conference held in Chicago has uncovered yet another benefit for red wine and resveratrol: that of protecting humans from food-borne illnesses.
Azlin Mustapha, who is an associate professor of food science in the College of Agriculture, Food and Natural Resources at the University of Missouri-Columbia, and food science program doctoral student Atreyee Das are investigating the effects of grape juice and various red wines on harmful as well as helpful bacteria in the intestinal tract. Commonly used antibiotics can destroy the body’s beneficial bacteria, which help combat elevated cholesterol and even tumors, among other positive effects.
The duo discovered that red wines, particularly Cabernet, Pinot noir and Merlot, inhibit food borne pathogens including E. coli, Salmonella Typhimurium, Listeria monocytogenes, and Helicobacter pylori, without harming beneficial probiotic bacteria. The most promising results were those found for H. pylori, which is the bacterium that causes most stomach ulcers. Ethanol (the alcohol that occurs in wine), pH levels and resveratrol were separately found have similar effects. While grape juice was also effective, white wine was not.
“It’s not just ethanol in the red wine that is inhibitory toward food-borne pathogens, but other factors which include the pH of the wine – because wines are a little acidic, and possibly the phytochemicals may have an effect,” Dr Mustapha observed. “We hypothesize that these phytochemicals, resveratrol being the main one, also play a role not just as antioxidants but also may have some inhibitions against food-borne pathogens. Now, we’re concentrating mainly on the resveratrol effects on these pathogens.”
“Our study is a little different than those previously reported in the media. Those studies promote moderate red wine consumption for cardiovascular diseases,” Dr Mustapha noted. “We went a step farther and asked: If red wine is already good for cardiovascular diseases, what about food-borne pathogens? If you get a food-borne illness and drink red wine, will that help decrease the symptoms a little bit? This study showed that the four probiotics tested weren’t inhibited by red wines; the pathogens were.”
Infectious diarrhea is a leading cause of morbidity and mortality worldwide (Marignani M et al 2004; Reinert P 1993). In the United States, 100 million people are affected by acute diarrhea every year. Most diarrhea is viral (not bacterial) in origin, but bacteria remain an important cause. Nearly half of patients with acute diarrhea must restrict activities, 10 percent consult physicians, 250,000 require hospitalization, and approximately 3000 die. Common bacterial pathogens that cause diarrhea include Campylobacter species, salmonella, shigella, and E. coli O157:H7.
Probiotics are bacterial cultures contained in yogurt, buttermilk, cheese, kefir, and sauerkraut, or in dietary supplements that contain friendly bacteria (such as Lactobacillus, Bifidobacterium, Eubacterium, and Propionibacterium species) normally present on skin and in vaginal, urinary, and intestinal tracts. These bacteria are essential to the proper function of the vaginal, urinary, and digestive tracts (Bengmark S 1998; Cunningham-Rundles S et al 2000; Dani C et al 2002).
Probiotics assist immune function by inhibiting harmful bacterial growth, promoting good digestion, maintaining proper pH, and enhancing immune function (Perdigon G et al 1995). Probiotics produce bacteria-inhibiting substances (natural antibiotics) and prevent harmful bacteria from attaching to vaginal, urinary, and intestinal tract mucosal linings (Ochmanski W et al 1999; Vaughan EE et al 1999). Probiotics have demonstrated In vitro ability to suppress H. pylori (Cremonini F et al 2001; Drouin E 1999; Felley C et al 2003; Johnson-Henry KC et al 2004; Wang KY et al 2004).
Antibiotics often destroy friendly bacteria on skin and in urinary, vaginal, and intestinal tracts. Probiotics can be used to recolonize and restore natural floral balance in organ and body systems after antibiotic treatment (Fooks LJ et al 2002; Guarner F et al 2003; Shi HN et al 2004).
Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by vitis vinifera as a response to attack by molds. Because of the wide-spread use of pesticides in modern wine-making, including the practice of copper sulphation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest, and other factors. In fact, usually only 1-3 mg resveratrol per liter of red wine is currently found, even in the most robust red wines.
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When beneficial intestinal bacteria are destroyed by antibiotics, digestive problems, poor absorption of food and nutrients, fungal infections, and generation of toxins by harmful intestinal bacteria may occur. The bacteria contained in Life Flora™ can recolonize the GI tract with beneficial bacteria, helping to end digestive problems and drive out the harmful, toxic bacteria.
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